RANBP1

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RANBP1
Protein RANBP1 PDB 1k5d.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RANBP1 , HTF9A, RAN binding protein 1
External IDs OMIM: 601180 MGI: 96269 HomoloGene: 21600 GeneCards: RANBP1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278639
NM_001278640
NM_001278641
NM_002882

NM_011239

RefSeq (protein)

NP_001265568
NP_001265569
NP_001265570
NP_002873

NP_035369

Location (UCSC) Chr 22: 20.12 – 20.13 Mb Chr 16: 18.06 – 18.07 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene. [5] [6] [7]

Contents

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [7]

Interactions

RANBP1 has been shown to interact with XPO1, [8] [9] KPNB1 [9] [10] and Ran. [9] [11] [12]

Related Research Articles

<span class="mw-page-title-main">Ran (protein)</span> GTPase functioning in nuclear transport

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

<span class="mw-page-title-main">KPNB1</span> Protein-coding gene in the species Homo sapiens

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

<span class="mw-page-title-main">RAS p21 protein activator 1</span> Protein-coding gene in the species Homo sapiens

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

<span class="mw-page-title-main">RANBP2</span> Protein-coding gene in the species Homo sapiens

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

<span class="mw-page-title-main">CDC6</span> Protein-coding gene in the species Homo sapiens

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

<span class="mw-page-title-main">RCC1</span> Protein-coding gene in the species Homo sapiens

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

<span class="mw-page-title-main">Nucleoporin 153</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

<span class="mw-page-title-main">CTBP1</span> Protein-coding gene in the species Homo sapiens

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

<span class="mw-page-title-main">Activating transcription factor 2</span> Protein-coding gene in the species Homo sapiens

Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene.

<span class="mw-page-title-main">RANGAP1</span> Protein-coding gene in the species Homo sapiens

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

<span class="mw-page-title-main">RHOQ</span> Protein-coding gene in the species Homo sapiens

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.

<span class="mw-page-title-main">EIF2S2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

<span class="mw-page-title-main">RRAS2</span> Protein-coding gene in the species Homo sapiens

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.

<span class="mw-page-title-main">SMARCD1</span> Protein-coding gene in the species Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.

<span class="mw-page-title-main">EIF5</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

<span class="mw-page-title-main">IPO7</span> Protein-coding gene in the species Homo sapiens

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

<span class="mw-page-title-main">NXT1</span> Protein-coding gene in the species Homo sapiens

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

<span class="mw-page-title-main">RANBP3</span> Protein-coding gene in the species Homo sapiens

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.

<span class="mw-page-title-main">XPOT</span> Protein-coding gene in the species Homo sapiens

Exportin-T is a protein that in humans is encoded by the XPOT gene.

<span class="mw-page-title-main">CENTG3</span> Protein-coding gene in the species Homo sapiens

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000099901 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005732 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol Gen Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID   7616957. S2CID   24266692.
  6. Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L (July 1999). "A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export". J Cell Biol. 145 (4): 645–57. doi:10.1083/jcb.145.4.645. PMC   2133185 . PMID   10330396.
  7. 1 2 "Entrez Gene: RANBP1 RAN binding protein 1".
  8. Singh, B B; Patel H H; Roepman R; Schick D; Ferreira P A (December 1999). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1". J. Biol. Chem. 274 (52): 37370–8. doi: 10.1074/jbc.274.52.37370 . ISSN   0021-9258. PMID   10601307.
  9. 1 2 3 Plafker, K; Macara I G (May 2000). "Facilitated Nucleocytoplasmic Shuttling of the Ran Binding Protein RanBP1". Mol. Cell. Biol. 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. ISSN   0270-7306. PMC   85643 . PMID   10779340.
  10. Yaseen, N R; Blobel G (September 1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358". J. Biol. Chem. 274 (37): 26493–502. doi: 10.1074/jbc.274.37.26493 . ISSN   0021-9258. PMID   10473610.
  11. Ren, M; Villamarin A; Shih A; Coutavas E; Moore M S; LoCurcio M; Clarke V; Oppenheim J D; D'Eustachio P; Rush M G (April 1995). "Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing". Mol. Cell. Biol. 15 (4): 2117–24. doi:10.1128/MCB.15.4.2117. ISSN   0270-7306. PMC   230439 . PMID   7891706.
  12. Steggerda, S M; Paschal B M (July 2000). "The mammalian Mog1 protein is a guanine nucleotide release factor for Ran". J. Biol. Chem. 275 (30): 23175–80. doi: 10.1074/jbc.C000252200 . ISSN   0021-9258. PMID   10811801.

Further reading