RANBP3

RANBP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRF, 2Y8F, 2Y8G
Identifiers
Aliases	RANBP3 , RAN binding protein 3
External IDs	OMIM: 603327; MGI: 1919060; HomoloGene: 136516; GeneCards: RANBP3; OMA:RANBP3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 5,916,139 bp [1] End 5,978,142 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 D Start 56,980,294 bp [2] End 57,018,764 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone ganglionic eminence stromal cell of endometrium gallbladder left testis muscle layer of sigmoid colon gastric mucosa popliteal artery tibial arteries Top expressed in spermatocyte ventricular zone epiblast Ileal epithelium yolk sac neural layer of retina primitive streak spermatid secondary oocyte dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function R-SMAD binding protein binding GTPase activator activity Cellular component nucleoplasm nucleus cytoplasm centrosome nuclear pore Biological process protein transport intracellular transport RNA export from nucleus ubiquitin-dependent protein catabolic process protein import into nucleus spindle organization positive regulation of GTPase activity positive regulation of mitotic centrosome separation G1/S transition of mitotic cell cycle protein export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8498 71810 Ensembl ENSG00000031823 ENSMUSG00000002372 UniProt Q9H6Z4 Q9CT10 RefSeq (mRNA) NM_001300865 NM_003624 NM_007320 NM_007321 NM_007322 NM_001252466 NM_001252467 NM_027933 RefSeq (protein) NP_001287794 NP_003615 NP_015559 NP_015561 NP_001239395 NP_001239396 NP_082209 Location (UCSC) Chr 19: 5.92 – 5.98 Mb Chr 17: 56.98 – 57.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene. ^{[5] [6]}

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[6]

Interactions

RANBP3 has been shown to interact with RCC1 ^{[5] [7]} and XPO1. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000031823 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002372 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID   9637251. S2CID   28405923.
6. "Entrez Gene: RANBP3 RAN binding protein 3".
7. Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . ISSN   0021-9258. PMID   11932251.
8. Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN   0021-9525. PMC   2150735 . PMID   11425870.
9. Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi: 10.1016/S0092-8674(02)00836-X . ISSN   0092-8674. PMID   12176322. S2CID   15515037.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Lindsay ME, Holaska JM, Welch K, et al. (2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. PMC   2150735 . PMID   11425870.
• Englmeier L, Fornerod M, Bischoff FR, et al. (2002). "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates". EMBO Rep. 2 (10): 926–32. doi:10.1093/embo-reports/kve200. PMC   1084078 . PMID   11571268.
• Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . PMID   11932251.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hakata Y, Yamada M, Shida H (2003). "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein". Mol. Cell. Biol. 23 (23): 8751–61. doi:10.1128/MCB.23.23.8751-8761.2003. PMC   262658 . PMID   14612415.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.