RANBP3

Last updated
RANBP3
Protein RANBP3 PDB 2crf.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RANBP3 , RAN binding protein 3
External IDs OMIM: 603327 MGI: 1919060 HomoloGene: 136516 GeneCards: RANBP3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300865
NM_003624
NM_007320
NM_007321
NM_007322

Contents

NM_001252466
NM_001252467
NM_027933

RefSeq (protein)

NP_001287794
NP_003615
NP_015559
NP_015561

NP_001239395
NP_001239396
NP_082209

Location (UCSC) Chr 19: 5.92 – 5.98 Mb Chr 17: 56.98 – 57.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene. [5] [6]

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [6]

Interactions

RANBP3 has been shown to interact with RCC1 [5] [7] and XPO1. [8] [9]

Related Research Articles

<span class="mw-page-title-main">Ran (protein)</span> GTPase functioning in nuclear transport

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

<span class="mw-page-title-main">Nuclear pore glycoprotein p62</span> Protein-coding gene in the species Homo sapiens

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

<span class="mw-page-title-main">XPO1</span> Protein-coding gene in the species Homo sapiens

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

<span class="mw-page-title-main">RANBP2</span> Protein-coding gene in the species Homo sapiens

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

<span class="mw-page-title-main">PGK1</span> Protein-coding gene in the species Homo sapiens

Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in humans

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">RCC1</span> Protein-coding gene in the species Homo sapiens

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

<span class="mw-page-title-main">Nucleoporin 153</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

<span class="mw-page-title-main">KIF22</span> Protein-coding gene in the species Homo sapiens

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.

<span class="mw-page-title-main">RANBP1</span> Protein-coding gene in the species Homo sapiens

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

<span class="mw-page-title-main">MYBBP1A</span> Protein-coding gene in the species Homo sapiens

Myb-binding protein 1A is a protein that in humans is encoded by the MYBBP1A gene.

<span class="mw-page-title-main">Nucleoporin 50</span> Protein-coding gene in the species Homo sapiens

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

<span class="mw-page-title-main">IPO7</span> Protein-coding gene in the species Homo sapiens

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

<span class="mw-page-title-main">HIVEP1</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

<span class="mw-page-title-main">NXT1</span> Protein-coding gene in the species Homo sapiens

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

<span class="mw-page-title-main">BCLAF1</span> Protein-coding gene in the species Homo sapiens

Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.

<span class="mw-page-title-main">CDC42EP1</span> Protein-coding gene in the species Homo sapiens

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

<span class="mw-page-title-main">EIF4ENIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.

<span class="mw-page-title-main">Muskelin</span> Protein-coding gene in the species Homo sapiens

Muskelin is a protein that in humans is encoded by the MKLN1 gene.

<span class="mw-page-title-main">ZNF346</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000031823 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002372 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID   9637251. S2CID   28405923.
  6. 1 2 "Entrez Gene: RANBP3 RAN binding protein 3".
  7. Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . ISSN   0021-9258. PMID   11932251.
  8. Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN   0021-9525. PMC   2150735 . PMID   11425870.
  9. Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi: 10.1016/S0092-8674(02)00836-X . ISSN   0092-8674. PMID   12176322. S2CID   15515037.

Further reading