RANBP3

RANBP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRF, 2Y8F, 2Y8G
Identifiers
Aliases	RANBP3 , RAN binding protein 3
External IDs	OMIM: 603327 MGI: 1919060 HomoloGene: 136516 GeneCards: RANBP3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,978,142 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,018,764 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ganglionic eminence; ; stromal cell of endometrium; ; gallbladder; ; gastric mucosa; ; popliteal artery; ; prefrontal cortex; ; right lobe of thyroid gland; ; canal of the cervix; ; anterior pituitary;
	Top expressed in
	spermatocyte; ; yolk sac; ; primitive streak; ; spermatid; ; secondary oocyte; ; neural tube; ; somite; ; seminiferous tubule; ; superior frontal gyrus; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	R-SMAD binding ; protein binding ; GTPase activator activity ;
Cellular component	nucleoplasm ; nucleus ; cytoplasm ; centrosome ; nuclear pore ;
Biological process	protein transport ; intracellular transport ; RNA export from nucleus ; ubiquitin-dependent protein catabolic process ; protein import into nucleus ; spindle organization ; positive regulation of GTPase activity ; positive regulation of mitotic centrosome separation ; G1/S transition of mitotic cell cycle ; protein export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	8498
	71810
	ENSG00000031823
	ENSMUSG00000002372
	Q9H6Z4
	Q9CT10
	NM_001300865 ; NM_003624 ; NM_007320 ; NM_007321 ; NM_007322 Contents Interactions ; References ; Further reading ;
	NM_001252466 ; NM_001252467 ; NM_027933
	NP_001287794 ; NP_003615 ; NP_015559 ; NP_015561
	NP_001239395 ; NP_001239396 ; NP_082209
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.^[5]^[6]

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

RANBP3 has been shown to interact with RCC1 ^[5]^[7] and XPO1.^[8]^[9]

Related Research Articles

Ran also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.

Nuclear pore glycoprotein p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. It is also known as nucleoporin 358 (Nup358) since it is a member nucleoporin family that makes up the nuclear pore complex. RanBP2 has a mass of 358 kDa.

Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein.

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.

Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1 gene.

Myb-binding protein 1A is a protein that in humans is encoded by the MYBBP1A gene.

Nucleoporin 50 (Nup50) is a protein that in humans is encoded by the NUP50 gene.

Importin-7 is a protein that in humans is encoded by the IPO7 gene.

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.

Muskelin is a protein that in humans is encoded by the MKLN1 gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000031823 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002372 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251. S2CID 28405923.
1 2 "Entrez Gene: RANBP3 RAN binding protein 3".
↑ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . ISSN 0021-9258. PMID 11932251.
↑ Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735 . PMID 11425870.
↑ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi: 10.1016/S0092-8674(02)00836-X . ISSN 0092-8674. PMID 12176322. S2CID 15515037.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lindsay ME, Holaska JM, Welch K, et al. (2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. PMC 2150735 . PMID 11425870.
Englmeier L, Fornerod M, Bischoff FR, et al. (2002). "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates". EMBO Rep. 2 (10): 926–32. doi:10.1093/embo-reports/kve200. PMC 1084078 . PMID 11571268.
Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . PMID 11932251.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hakata Y, Yamada M, Shida H (2003). "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein". Mol. Cell. Biol. 23 (23): 8751–61. doi:10.1128/MCB.23.23.8751-8761.2003. PMC 262658 . PMID 14612415.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000031823 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002372 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9637251-5] 1 2 Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251. S2CID 28405923.

[entrez-6] 1 2 "Entrez Gene: RANBP3 RAN binding protein 3".

[pmid11932251-7] Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. 277 (20): 17385–8. doi: 10.1074/jbc.C100620200 . ISSN 0021-9258. PMID 11932251.

[pmid11425870-8] Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735 . PMID 11425870.

[pmid12176322-9] Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349–60. doi: 10.1016/S0092-8674(02)00836-X . ISSN 0092-8674. PMID 12176322. S2CID 15515037.

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RANBP3

Contents

Interactions

Related Research Articles

References

Further reading