RANBP9

Last updated
RANBP9
Identifiers
Aliases RANBP9 , Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9
External IDs OMIM: 603854 MGI: 1928741 HomoloGene: 38057 GeneCards: RANBP9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005493

NM_019930

RefSeq (protein)

NP_005484

NP_064314
NP_001391577

Location (UCSC) Chr 6: 13.62 – 13.71 Mb Chr 13: 43.56 – 43.63 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene. [5] [6]

Contents

Function

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [6]

Interactions

RANBP9 has been shown to interact with:

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010017 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038546 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nakamura M, Masuda H, Horii J, Kuma Ki, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec 1998). "When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin". J Cell Biol. 143 (4): 1041–52. doi:10.1083/jcb.143.4.1041. PMC   2132962 . PMID   9817760.
  6. 1 2 "Entrez Gene: RANBP9 RAN binding protein 9".
  7. 1 2 Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS (Dec 2002). "RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor". J. Biol. Chem. 277 (50): 48020–7. doi: 10.1074/jbc.M209741200 . PMID   12361945.
  8. Wang D, Li Z, Messing EM, Wu G (Sep 2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM". J. Biol. Chem. 277 (39): 36216–22. doi: 10.1074/jbc.M205111200 . PMID   12147692.
  9. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID   12812986.
  10. Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi: 10.1074/jbc.M307556200 . PMID   14500717.
  11. Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H (Sep 2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. PMID   12220523.
  12. Umeda M, Nishitani H, Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/s0378-1119(02)01153-8. PMID   12559565.
  13. Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH (Nov 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer. 2: 28. doi: 10.1186/1471-2407-2-28 . PMC   137593 . PMID   12421467.
  14. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y (Oct 2002). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC   1222860 . PMID   12084015.

Further reading