RHOJ

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RHOJ
Identifiers
Aliases	RHOJ , ARHJ, RASL7B, TC10B, TCL, ras homolog family member J
External IDs	OMIM: 607653 MGI: 1931551 HomoloGene: 56894 GeneCards: RHOJ
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.2 Start 63,204,114 bp [1] End 63,293,508 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 75,355,096 bp [2] End 75,448,230 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve smooth muscle tissue gallbladder left uterine tube upper lobe of left lung endothelial cell lower lobe of lung visceral pleura subcutaneous adipose tissue ganglionic eminence Top expressed in semi-lunar valve aortic valve belly cord ascending aorta external carotid artery internal carotid artery ciliary body parotid gland iris right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity protein kinase binding Cellular component cytosol plasma membrane extracellular exosome membrane intracellular anatomical structure cytoplasm cell cortex cell projection Biological process regulation of small GTPase mediated signal transduction retina vasculature morphogenesis in camera-type eye actin cytoskeleton organization Rho protein signal transduction regulation of cell shape small GTPase mediated signal transduction angiogenesis endocytosis actin filament organization establishment or maintenance of cell polarity regulation of endothelial cell migration cell projection assembly regulation of actin cytoskeleton organization positive regulation of cell migration involved in sprouting angiogenesis regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57381 80837 Ensembl ENSG00000126785 ENSMUSG00000046768 UniProt Q9H4E5 Q9ER71 RefSeq (mRNA) NM_020663 NM_023275 RefSeq (protein) NP_065714 NP_065714.1 NP_075764 Location (UCSC) Chr 14: 63.2 – 63.29 Mb Chr 12: 75.36 – 75.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene. ^{[5] [6]}

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000126785 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046768 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 and Ccdc42". J Biol Chem. 275 (46): 36457–64. doi: 10.1074/jbc.M003487200 . PMID   10967094.
6. "Entrez Gene: RHOJ ras homolog gene family, member J".

Further reading

• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID   15710388. S2CID   36721405.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology". FEBS Lett. 572 (1–3): 159–66. doi: 10.1016/j.febslet.2004.06.095 . PMID   15304341. S2CID   9107914.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway". Mol. Biol. Cell. 14 (12): 4846–56. doi:10.1091/mbc.E03-04-0254. PMC   284789 . PMID   12960428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.