RNA-binding protein 8A

RBM8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P27, 2HYI, 2J0Q, 2J0S, 2XB2, 3EX7
Identifiers
Aliases	RBM8A , BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1, RNA binding motif protein 8A
External IDs	OMIM: 605313; MGI: 1913129; HomoloGene: 3744; GeneCards: RBM8A; OMA:RBM8A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.1 Start 145,921,556 bp [1] End 145,927,678 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,537,249 bp [2] End 96,541,107 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Achilles tendon olfactory zone of nasal mucosa gastrocnemius muscle islet of Langerhans skin of abdomen monocyte right testis left testis Top expressed in embryo embryo interventricular septum ventricular zone blastocyst yolk sac morula dentate gyrus of hippocampal formation granule cell epiblast neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding mRNA binding Cellular component cytosol catalytic step 2 spliceosome exon-exon junction complex soma dendrite spliceosomal complex nucleus cytoplasm nucleoplasm nuclear speck U2-type catalytic step 1 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA transport RNA processing mRNA processing regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus mRNA 3'-end processing regulation of translation RNA export from nucleus nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA splicing transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9939 60365 Ensembl ENSG00000265241 ENSMUSG00000038374 UniProt Q9Y5S9 Q9CWZ3 RefSeq (mRNA) NM_005105 NM_001102407 NM_025875 RefSeq (protein) NP_005096 NP_001095877 NP_080151 Location (UCSC) Chr 1: 145.92 – 145.93 Mb Chr 3: 96.54 – 96.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

RNA-binding protein 8A is a protein that in humans is encoded by the RBM8A gene. ^{[5] [6]}

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites. ^[7]

Interactions

RBM8A has been shown to interact with IPO13, ^[8] MAGOH ^{[9] [10]} and UPF3A. ^[11]

Related gene problems

• TAR syndrome ^[12]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000265241 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038374 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Conklin DC, Rixon MW, Kuestner RE, Maurer MF, Whitmore TE, Millar RP (October 2000). "Cloning and gene expression of a novel human ribonucleoprotein". Biochim Biophys Acta. 1492 (2–3): 465–9. doi:10.1016/s0167-4781(00)00090-7. PMID   11004516.
6. Salicioni AM, Xi M, Vanderveer LA, Balsara B, Testa JR, Dunbrack RL Jr, Godwin AK (October 2000). "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor". Genomics. 69 (1): 54–62. doi:10.1006/geno.2000.6315. PMID   11013075.
7. "Entrez Gene: RBM8A RNA binding motif protein 8A".
8. Mingot, J M; Kostka S; Kraft R; Hartmann E; Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14). England: 3685–94. doi:10.1093/emboj/20.14.3685. ISSN   0261-4189. PMC   125545 . PMID   11447110.
9. Zhao, X F; Nowak N J; Shows T B; Aplan P D (January 2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. 63 (1). UNITED STATES: 145–8. doi:10.1006/geno.1999.6064. ISSN   0888-7543. PMID   10662555.
10. Kataoka, N; Diem M D; Kim V N; Yong J; Dreyfuss G (November 2001). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex". EMBO J. 20 (22). England: 6424–33. doi:10.1093/emboj/20.22.6424. ISSN   0261-4189. PMC   125744 . PMID   11707413.
11. Kim, V N; Kataoka N; Dreyfuss G (September 2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science . 293 (5536). United States: 1832–6. Bibcode:2001Sci...293.1832K. doi:10.1126/science.1062829. ISSN   0036-8075. PMID   11546873. S2CID   12018200.
12. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC   1785342 . PMID   17236129.

Further reading

• Wilson KF, Fortes P, Singh US, et al. (1999). "The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction". J. Biol. Chem. 274 (7): 4166–73. doi: 10.1074/jbc.274.7.4166 . PMID   9933612.
• Zhao XF, Nowak NJ, Shows TB, Aplan PD (2000). "MAGOH interacts with a novel RNA-binding protein". Genomics. 63 (1): 145–8. doi:10.1006/geno.1999.6064. PMID   10662555.
• Kataoka N, Yong J, Kim VN, et al. (2000). "Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm". Mol. Cell. 6 (3): 673–82. doi: 10.1016/S1097-2765(00)00065-4 . PMID   11030346.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2001). "The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMC   305905 . PMID   11118221.
• Mingot JM, Kostka S, Kraft R, et al. (2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC   125545 . PMID   11447110.
• Kim VN, Kataoka N, Dreyfuss G (2001). "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex". Science. 293 (5536): 1832–6. Bibcode:2001Sci...293.1832K. doi:10.1126/science.1062829. PMID   11546873. S2CID   12018200.
• Lykke-Andersen J, Shu MD, Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1". Science. 293 (5536): 1836–9. Bibcode:2001Sci...293.1836L. doi:10.1126/science.1062786. PMID   11546874. S2CID   389385.
• Hachet O, Ephrussi A (2002). "Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport". Curr. Biol. 11 (21): 1666–74. doi: 10.1016/S0960-9822(01)00508-5 . PMID   11696323. S2CID   2373806.
• Faurholm B, Millar RP, Katz AA (2002). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID   11707068.
• Kataoka N, Diem MD, Kim VN, et al. (2002). "Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon–exon junction complex". EMBO J. 20 (22): 6424–33. doi:10.1093/emboj/20.22.6424. PMC   125744 . PMID   11707413.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Okubo K, Mitani H, Naruse K, et al. (2002). "Conserved physical linkage of GnRH-R and RBM8 in the medaka and human genomes". Biochem. Biophys. Res. Commun. 293 (1): 327–31. doi:10.1016/S0006-291X(02)00161-4. PMID   12054603.
• Lejeune F, Ishigaki Y, Li X, Maquat LE (2002). "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling". EMBO J. 21 (13): 3536–45. doi:10.1093/emboj/cdf345. PMC   126094 . PMID   12093754.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gehring NH, Neu-Yilik G, Schell T, et al. (2003). "Y14 and hUpf3b form an NMD-activating complex". Mol. Cell. 11 (4): 939–49. doi: 10.1016/S1097-2765(03)00142-4 . PMID   12718880.
• Fribourg S, Gatfield D, Izaurralde E, Conti E (2003). "A novel mode of RBD-protein recognition in the Y14-Mago complex". Nat. Struct. Biol. 10 (6): 433–9. doi:10.1038/nsb926. PMID   12730685. S2CID   40116577.
• Lau CK, Diem MD, Dreyfuss G, Van Duyne GD (2004). "Structure of the Y14-Magoh core of the exon junction complex". Curr. Biol. 13 (11): 933–41. doi: 10.1016/S0960-9822(03)00328-2 . PMID   12781131. S2CID   14752714.