E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene. [5]
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [5]
RNF216 has been shown to interact with TLR9 [6] and RIPK1. [7]
40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.
Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.
E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.
RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.
E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.
E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.
Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene. Alternative splicing results in multiple transcript variants.
Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.
E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.
RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene.
Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.
E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.
RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.
RING finger protein 115 is a protein, that in humans, is encoded by the RNF115 gene.
Ring finger protein 5 pseudogene 1, also known as RNF5P1, is a human gene.
E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.
Ring finger protein 24 is a protein that in humans is encoded by the RNF24 gene.