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A retinal ganglion cell (RGC) is a type of neuron located near the inner surface of the retina of the eye. It receives visual information from photoreceptors via two intermediate neuron types: bipolar cells and retina amacrine cells. Retina amacrine cells, particularly narrow field cells, are important for creating functional subunits within the ganglion cell layer and making it so that ganglion cells can observe a small dot moving a small distance. Retinal ganglion cells collectively transmit image-forming and non-image forming visual information from the retina in the form of action potential to several regions in the thalamus, hypothalamus, and mesencephalon, or midbrain.
Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4. In the mammalian retina, there are two additional categories of opsins, both involved in the formation of visual images: rhodopsin and photopsin in the rod and cone photoreceptor cells, respectively.
Motion perception is the process of inferring the speed and direction of elements in a scene based on visual, vestibular and proprioceptive inputs. Although this process appears straightforward to most observers, it has proven to be a difficult problem from a computational perspective, and difficult to explain in terms of neural processing.
Amacrine cells are interneurons in the retina. They are named from the Greek roots a– ("non"), makr– ("long") and in– ("fiber"), because of their short neuronal processes. Amacrine cells are inhibitory neurons, and they project their dendritic arbors onto the inner plexiform layer (IPL), they interact with retinal ganglion cells and/or bipolar cells.
Intrinsically photosensitive retinal ganglion cells (ipRGCs), also called photosensitive retinal ganglion cells (pRGC), or melanopsin-containing retinal ganglion cells (mRGCs), are a type of neuron in the retina of the mammalian eye. The presence of ipRGCs was first suspected in 1927 when rodless, coneless mice still responded to a light stimulus through pupil constriction, This implied that rods and cones are not the only light-sensitive neurons in the retina. Yet research on these cells did not advance until the 1980s. Recent research has shown that these retinal ganglion cells, unlike other retinal ganglion cells, are intrinsically photosensitive due to the presence of melanopsin, a light-sensitive protein. Therefore they constitute a third class of photoreceptors, in addition to rod and cone cells.
Carla J. Shatz is an American neurobiologist and an elected member of the American Academy of Arts and Sciences, the American Philosophical Society, the National Academy of Sciences, and the National Academy of Medicine.
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.
A parasol cell, sometimes called an M cell or M ganglion cell, is one type of retinal ganglion cell (RGC) located in the ganglion cell layer of the retina. These cells project to magnocellular cells in the lateral geniculate nucleus (LGN) as part of the magnocellular pathway in the visual system. They have large cell bodies as well as extensive branching dendrite networks and as such have large receptive fields. Relative to other RGCs, they have fast conduction velocities. While they do show clear center-surround antagonism, they receive no information about color. Parasol ganglion cells contribute information about the motion and depth of objects to the visual system.
Christine Elizabeth Holt FRS, FMedSci is a British developmental neuroscientist.
Retinal waves are spontaneous bursts of action potentials that propagate in a wave-like fashion across the developing retina. These waves occur before rod and cone maturation and before vision can occur. The signals from retinal waves drive the activity in the dorsal lateral geniculate nucleus (dLGN) and the primary visual cortex. The waves are thought to propagate across neighboring cells in random directions determined by periods of refractoriness that follow the initial depolarization. Retinal waves are thought to have properties that define early connectivity of circuits and synapses between cells in the retina. There is still much debate about the exact role of retinal waves. Some contend that the waves are instructional in the formation of retinogeniculate pathways, while others argue that the activity is necessary but not instructional in the formation of retinogeniculate pathways.
King-Wai Yau is a Chinese-born American neuroscientist and Professor of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, Maryland.
Samer Hattar is a chronobiologist and a leader in the field of non-image forming photoreception. He is the Chief of the Section on Light and Circadian Rhythms at the National Institute of Mental Health, part of the National Institutes of Health. He was previously an associate professor in the Department of Neuroscience and the Department of Biology at Johns Hopkins University in Baltimore, MD. He is best known for his investigation into the role of melanopsin and intrinsically photosensitive retinal ganglion cells (ipRGC) in the entrainment of circadian rhythms.
Douglas G. McMahon is a professor of Biological Sciences and Pharmacology at Vanderbilt University. McMahon has contributed several important discoveries to the field of chronobiology and vision. His research focuses on connecting the anatomical location in the brain to specific behaviors. As a graduate student under Gene Block, McMahon identified that the basal retinal neurons (BRNs) of the molluscan eye exhibited circadian rhythms in spike frequency and membrane potential, indicating they are the clock neurons. He became the 1986 winner of the Society for Neuroscience's Donald B. Lindsley Prize in Behavioral Neuroscience for his work. Later, he moved on to investigate visual, circadian, and serotonergic mechanisms of neuroplasticity. In addition, he helped find that constant light can desynchronize the circadian cells in the suprachiasmatic nucleus (SCN). He has always been interested in the underlying causes of behavior and examining the long term changes in behavior and physiology in the neurological modular system. McMahon helped identifying a retrograde neurotransmission system in the retina involving the melanopsin containing ganglion cells and the retinal dopaminergic amacrine neurons.
Dr. Andrew D. Huberman is an American neuroscientist and tenured associate professor in the Department of Neurobiology and Psychiatry and Behavioral Sciences at Stanford University School of Medicine who has made contributions to the fields of brain development, brain plasticity, and neural regeneration and repair. Much of his work is focused on the visual system, including the mechanisms controlling light-mediated activation of the circadian and autonomic arousal centers in the brain, as well as brain control over conscious vision or sight. Huberman has been credited with coining the term "Non-Sleep Deep Rest", which he earlier referred to as Yoga Nidra. These practices place the brain and body into shallow sleep to accelerate neuroplasticity and help offset mental and physical fatigue.
Carol Ann Mason is a Professor of Pathology and Cell Biology at Columbia University in the Mortimer B. Zuckerman Mind Brain Behavior Institute. She studies axon guidance in visual pathways in an effort to restore vision to the blind. Her research focuses on the retinal ganglion cell. She was elected a member of the National Academy of Sciences in 2018.
Marla Beth Feller is the Paul Licht Distinguished Professor in Biological Sciences and Member of the Helen Wills Neuroscience Institute at the University of California, Berkeley. She studies the mechanisms that underpin the assembly of neural circuits during development. Feller is a Fellow of the American Association for the Advancement of Science.
Adrienne Fairhall is a University Professor in the Department of Physiology and Biophysics and an adjunct Professor in the Departments of Physics and Applied Mathematics, as well as the director of the Computational Neuroscience Program and co-director of the Institute for Neuroengineering at the University of Washington.
Laura Busse is a German neuroscientist and professor of Systemic Neuroscience within the Division of Neurobiology at the Ludwig Maximilian University of Munich. Busse's lab studies context-dependent visual processing in mouse models by performing large scale in vivo electrophysiological recordings in the thalamic and cortical circuits of awake and behaving mice.
Susan Ellen Shore is an American audiologist who is the Merle Lawrence Collegiate Professor of Otolaryngology at the University of Michigan. She was elected Fellow of the American Association for the Advancement of Science in 2021.
Tiffany M. Schmidt is an American researcher and chronobiologist, currently working as an Associate Professor of Neurobiology at Northwestern University. Schmidt, who works in Evanston, Illinois, studies the role of retinal ganglion cells (RGC) to determine how light can affect behavior, hormonal changes, vision, sleep, and circadian entrainment.
References
- 1 2 3 4 5 6 7 "179: Dr. Rachel Wong: A Researcher with an Eye for Great Science Studying Retinal Cell Rewiring After Damage". People Behind the Science Podcast. 2014-11-12. Retrieved 2021-04-27.
- ↑ Wong, Rachel Oi Lun (1985). "Ontogeny of the cat retinal ganglion cell layer". doi:10.25911/5d651306e496d.
{{cite journal}}: Cite journal requires|journal=(help) - ↑ "Rachel Wong Laboratory". depts.washington.edu. Retrieved 2021-04-27.
- ↑ "Rachel Wong | Graduate Program in Neuroscience" . Retrieved 2021-04-27.
- ↑ "Audacious Goals Initiative". www.nei.nih.gov. Retrieved 2021-04-27.
- ↑ "NVRI Fellowship". Australian College of Optometry. Retrieved 2021-04-27.
- ↑ "2021 NAS Election". www.nasonline.org. Retrieved 2021-04-27.
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