Rafoxanide

Rafoxanide
Names
	Preferred IUPAC name N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
	Other names Rafoxanid, raphoxanide
Identifiers
CAS Number	22662-39-1 ;
3D model (JSmol)	Interactive image ;
ChEBI	CHEBI:234200 ;
ChEMBL	ChEMBL287542 ;
ChemSpider	29191 ;
ECHA InfoCard	100.041.029
EC Number	245-148-9;
KEGG	D05693 ;
MeSH	D011888
PubChem CID	31475 ;
UNII	22F4FLA7DH ;
CompTox Dashboard (EPA)	DTXSID5046227 ;
	InChI InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) Key: NEMNPWINWMHUMR-UHFFFAOYSA-N ; InChI=1/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) Key: NEMNPWINWMHUMR-UHFFFAOYAP;
	SMILES C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=CC(=CC(=C3O)I)I)Cl)Cl;
Properties
Chemical formula	C19H11Cl2I2NO3
Molar mass	626.01 g/mol
Appearance	Slight yellowish-brown injectable solution and white oral solution
Solubility in water	In oily solutes
Pharmacology
ATCvet code	QP52AG05 ( WHO )
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Has low safety index (6 times as normal dose)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Last updated June 21, 2025

Rafoxanide is a salicylanilide used as an anthelmintic.^[1] It is most commonly used in ruminant animals to treat adult liver flukes of the species Fasciola hepatica and Fasciola gigantica .^[1]

References

1 2 Lanusse, Carlos E.; Alvarez, Luis I.; Virkel, Guillermo L. (2018). "Chapter 40. Anticestodal and antitrematodal drugs. Rafoxanide". In Riviere, Jim E.; Papich, Mark G. (eds.). Veterinary Pharmacology and Therapeutics (10th ed.). John Wiley & Sons. p. 1091. ISBN 9781118855829.

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[Lanusse_2018-1] 1 2 Lanusse, Carlos E.; Alvarez, Luis I.; Virkel, Guillermo L. (2018). "Chapter 40. Anticestodal and antitrematodal drugs. Rafoxanide". In Riviere, Jim E.; Papich, Mark G. (eds.). Veterinary Pharmacology and Therapeutics (10th ed.). John Wiley & Sons. p. 1091. ISBN 9781118855829.

[1]

Names

Preferred IUPAC name N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
Other names Rafoxanid, raphoxanide
Identifiers
CAS Number	22662-39-1 ^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:234200
ChEMBL	ChEMBL287542 ^N
ChemSpider	29191 ^N
ECHA InfoCard	100.041.029
EC Number	245-148-9
KEGG	D05693 ^N
MeSH	D011888
PubChem CID	31475
UNII	22F4FLA7DH ^Y
CompTox Dashboard (EPA)	DTXSID5046227
InChI InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)^N Key: NEMNPWINWMHUMR-UHFFFAOYSA-N^N InChI=1/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) Key: NEMNPWINWMHUMR-UHFFFAOYAP
SMILES C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=CC(=CC(=C3O)I)I)Cl)Cl
Properties
Chemical formula	C₁₉H₁₁Cl₂I₂NO₃
Molar mass	626.01 g/mol
Appearance	Slight yellowish-brown injectable solution and white oral solution
Solubility in water	In oily solutes
Pharmacology
ATCvet code	QP52AG05 ( WHO )
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Has low safety index (6 times as normal dose)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references