Ro-318220

Last updated
Ro-318220
Ro-318220.svg
Names
Preferred IUPAC name
3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
PubChem CID
UNII
  • InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
    Key: DSXXEELGXBCYNQ-UHFFFAOYSA-N
  • InChI=1/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32)
    Key: DSXXEELGXBCYNQ-UHFFFAOYAO
  • Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(=N)N)c4ccccc34)c5ccccc15
Properties
C25H23N5O2S
Molar mass 457.55 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. [1]

References

  1. ↑ Beltman, Jerlyn; Frank McCormick; Simon J. Cook (1996). "The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun Expression, and Activates Jun N-terminal Kinase". Journal of Biological Chemistry. 271 (43): 27018–27024. doi: 10.1074/jbc.271.43.27018 . PMID   8900190.
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