Ronidazole

Last updated
Ronidazole
Ronidazole Structural Formula V.1.svg
Names
Preferred IUPAC name
(1-Methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.028.796 OOjs UI icon edit-ltr-progressive.svg
PubChem CID
UNII
  • InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)
  • O=C(OCc1ncc(n1C)[N+]([O-])=O)N
Properties
C6H8N4O4
Molar mass 200.154 g·mol−1
Pharmacology
QP51CA02 ( WHO )
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ronidazole is an antiprotozoal agent used in veterinary medicine for the treatment of histomoniasis and swine dysentery [1] [2] as well as Trichomonas gallinae, hexamitosis, Giardia, and Cochlosoma in all aviary birds and pigeons. [3] It may also have use for the treatment of Tritrichomonas foetus infection in cats [4] [5] [6] and for the treatment of Clostridioides difficile infection in humans. [7]

References

  1. ↑ Sullivan, T.W.; Grace, O.D.; Aksoy, Ayhan (1977-03-01). "Influence of Level, Timing and Duration of Ronidazole Water Medication on Histomoniasis in Turkeys1". Poultry Science. 56 (2): 571–576. doi: 10.3382/ps.0560571 . ISSN   0032-5791. PMID   564505.
  2. ↑ Olson, L. D.; Rodabaugh, D. E. (July 1976). "Ronidazole in low concentrations in drinking water for treatment and development of immunity to swine dysentery". American Journal of Veterinary Research. 37 (7): 763–767. ISSN   0002-9645. PMID   937800.
  3. ↑ "Ronidazole". All Bird Products. Archived from the original on 2021-05-14. Retrieved 2022-03-17.
  4. ↑ Gunn-Moore, Danielle; Lalor, Stephanie (2011-01-01). "Treatment of diarrhoea in cats caused by Tritrichomonas foetus" . Veterinary Record . 168 (2): 56–57. doi:10.1136/vr.d189. ISSN   0042-4900. PMID   21257565. S2CID   207041640. Archived from the original on 2022-03-17. Retrieved 2022-03-17.
  5. ↑ "Tritrichomonas foetus infection in cats and treatment with RONIDAZOLE" (PDF). University of Edinburgh . December 2009. Archived (PDF) from the original on 2022-03-17. Retrieved 2022-03-17.
  6. ↑ Davidson, Gigi S. (December 2006). "Ronidazole in the treatment of trichomonad infections in cats". International Journal of Pharmaceutical Compounding. 10 (6): 434–435. ISSN   1092-4221. PMID   23974416.
  7. ↑ AbdelKhalek, Ahmed; Seleem, Mohamed N. (December 2020). "Repurposing the Veterinary Antiprotozoal Drug Ronidazole for the Treatment of Clostridioides difficile Infection". International Journal of Antimicrobial Agents . 56 (6): 106188. doi:10.1016/j.ijantimicag.2020.106188. ISSN   1872-7913. PMC   7704610 . PMID   33045352.
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