S100A8

S100A8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MR8, 1XK4, 4GGF, 4XJK, 5HLO, 5HLV
Identifiers
Aliases	S100A8 , 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
External IDs	OMIM: 123885 MGI: 88244 HomoloGene: 2225 GeneCards: S100A8
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 153,390,032 bp [1] End 153,391,073 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F1|3 39.9 cM Start 90,668,978 bp [2] End 90,670,035 bp [2]
RNA expression pattern Bgee Top expressed in esophagus gums cavity of mouth thymus cervix vagina vulva bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Toll-like receptor 4 binding RAGE receptor binding microtubule binding GO:0001948 protein binding calcium ion binding arachidonic acid binding zinc ion binding metal ion binding Cellular component nucleus cytoskeleton cytosol extracellular exosome membrane plasma membrane cytoplasm extracellular space secretory granule lumen intermediate filament cytoskeleton extracellular region collagen-containing extracellular matrix Biological process regulation of inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process immune system process positive regulation of inflammatory response neutrophil chemotaxis positive regulation of intrinsic apoptotic signaling pathway defense response to fungus response to ethanol chemokine production response to zinc ion acute inflammatory response defense response to bacterium leukocyte migration involved in inflammatory response peptidyl-cysteine S-nitrosylation sequestering of zinc ion neutrophil aggregation response to lipopolysaccharide chemotaxis positive regulation of peptide secretion chronic inflammatory response astrocyte development wound healing apoptotic process positive regulation of cell growth autophagy inflammatory response regulation of cytoskeleton organization cytokine production positive regulation of NF-kappaB transcription factor activity innate immune response toll-like receptor signaling pathway antimicrobial humoral response neutrophil degranulation autocrine signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6279	20201
Ensembl	ENSG00000143546	ENSMUSG00000056054
UniProt	P05109	P27005
RefSeq (mRNA)	NM_002964 NM_001319196 NM_001319197 NM_001319198 NM_001319201	NM_013650
RefSeq (protein)	NP_001306125 NP_001306126 NP_001306127 NP_001306130 NP_002955	NP_038678
Location (UCSC)	Chr 1: 153.39 – 153.39 Mb	Chr 3: 90.67 – 90.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. ^[5] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis ^[5] and post COVID-19 condition. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143546 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056054 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: S100A8 S100 calcium binding protein A8".
6. Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC   8758383 . PMID   35027067.

Further reading

• Schäfer BW, Heizmann CW (April 1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends in Biochemical Sciences. 21 (4): 134–140. doi:10.1016/S0968-0004(96)80167-8. PMID   8701470.
• Kerkhoff C, Klempt M, Sorg C (December 1998). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)". Biochimica et Biophysica Acta. 1448 (2): 200–211. doi: 10.1016/S0167-4889(98)00144-X . PMID   9920411.
• Nacken W, Roth J, Sorg C, Kerkhoff C (April 2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microscopy Research and Technique. 60 (6): 569–580. doi:10.1002/jemt.10299. PMID   12645005. S2CID   10145841.
• Roth J, Vogl T, Sorg C, Sunderkötter C (April 2003). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends in Immunology. 24 (4): 155–158. doi:10.1016/S1471-4906(03)00062-0. PMID   12697438.
• Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (December 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–969. doi:10.1002/elps.11501301199. PMID   1286667. S2CID   41855774.
• Lemarchand P, Vaglio M, Mauël J, Markert M (September 1992). "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation". The Journal of Biological Chemistry. 267 (27): 19379–19382. doi: 10.1016/S0021-9258(18)41786-3 . PMID   1326551.
• Schäfer T, Sachse GE, Gassen HG (January 1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells". Biological Chemistry Hoppe-Seyler. 372 (1): 1–4. doi:10.1515/bchm3.1991.372.1.1. PMID   2039599.
• Dorin JR, Emslie E, van Heyningen V (November 1990). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics. 8 (3): 420–426. doi:10.1016/0888-7543(90)90027-R. PMID   2149559.
• Wilkinson MM, Busuttil A, Hayward C, Brock DJ, Dorin JR, Van Heyningen V (October 1988). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues". Journal of Cell Science. 91 ( Pt 2) (2): 221–230. doi:10.1242/jcs.91.2.221. PMID   3267695.
• Odink K, Cerletti N, Brüggen J, Clerc RG, Tarcsay L, Zwadlo G, et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis". Nature. 330 (6143): 80–82. Bibcode:1987Natur.330...80O. doi:10.1038/330080a0. PMID   3313057. S2CID   4366579.
• Lagasse E, Clerc RG (June 1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation". Molecular and Cellular Biology. 8 (6): 2402–2410. doi:10.1128/mcb.8.6.2402. PMC   363438 . PMID   3405210.
• Dorin JR, Novak M, Hill RE, Brock DJ, Secher DS, van Heyningen V (1987). "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene". Nature. 326 (6113): 614–617. Bibcode:1987Natur.326..614D. doi:10.1038/326614a0. PMID   3561500. S2CID   4242084.
• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (February 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–643. doi:10.1016/0888-7543(95)80005-7. PMID   7759097.
• Umekawa T, Kurita T (September 1994). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone". Biochemistry and Molecular Biology International. 34 (2): 309–313. PMID   7849642.
• Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW (July 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proceedings of the National Academy of Sciences of the United States of America. 90 (14): 6547–6551. Bibcode:1993PNAS...90.6547E. doi: 10.1073/pnas.90.14.6547 . PMC   46969 . PMID   8341667.
• Roth J, Burwinkel F, van den Bos C, Goebeler M, Vollmer E, Sorg C (September 1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner". Blood. 82 (6): 1875–1883. doi: 10.1182/blood.V82.6.1875.1875 . PMID   8400238.
• Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (February 1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". Journal of Dental Research. 72 (2): 517–523. doi:10.1177/00220345930720020801. PMID   8423249. S2CID   8311930.
• Marti T, Erttmann KD, Gallin MY (April 1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications. 221 (2): 454–458. doi:10.1006/bbrc.1996.0616. PMID   8619876.