SAE1

SAE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y8Q, 1Y8R, 3KYC, 3KYD
Identifiers
Aliases	SAE1 , AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1
External IDs	OMIM: 613294 MGI: 1929264 HomoloGene: 4019 GeneCards: SAE1
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 47,113,274 bp [1] End 47,210,636 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 A2|7 8.88 cM Start 16,054,159 bp [2] End 16,121,731 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence stromal cell of endometrium oocyte prefrontal cortex smooth muscle tissue popliteal artery gastric mucosa rectum Achilles tendon right lobe of thyroid gland Top expressed in primitive streak somite abdominal wall neural tube maxillary prominence yolk sac dermis hand medial ganglionic eminence endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin activating enzyme activity SUMO activating enzyme activity enzyme activator activity ligase activity protein C-terminus binding ubiquitin-like modifier activating enzyme activity protein binding ATP-dependent protein binding small protein activating enzyme binding protein heterodimerization activity Cellular component SUMO activating enzyme complex nucleus nucleoplasm cytoplasm Biological process protein sumoylation protein ubiquitination positive regulation of protein targeting to mitochondrion positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10055 56459 Ensembl ENSG00000142230 ENSMUSG00000052833 UniProt Q9UBE0 Q9R1T2 RefSeq (mRNA) NM_001145713 NM_001145714 NM_005500 NM_001285891 NM_001285892 NM_019748 RefSeq (protein) NP_001139185 NP_001139186 NP_005491 NP_001272820 NP_001272821 NP_062722 Location (UCSC) Chr 19: 47.11 – 47.21 Mb Chr 7: 16.05 – 16.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene. ^{[5] [6] [7] [8]}

Interactions

SAE1 has been shown to interact with SAE2, the protein product of the gene UBA2. ^{[5] [7] [9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000142230 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052833 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Desterro JM, Rodriguez MS, Kemp GD, Hay RT (May 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 10618–24. doi: 10.1074/jbc.274.15.10618 . PMID   10187858.
6. Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H (Mar 1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID   9920803.
7. Gong L, Li B, Millas S, Yeh ET (Jun 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 185–9. doi: 10.1016/S0014-5793(99)00367-1 . PMID   10217437. S2CID   7756078.
8. "Entrez Gene: SAE1 SUMO1 activating enzyme subunit 1".
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Tatham MH, Jaffray E, Vaughan OA, Desterro JM, Botting CH, Naismith JH, Hay RT (2001). "Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9". J. Biol. Chem. 276 (38): 35368–74. doi: 10.1074/jbc.M104214200 . PMID   11451954.
• Azuma Y, Tan SH, Cavenagh MM, Ainsztein AM, Saitoh H, Dasso M (2001). "Expression and regulation of the mammalian SUMO-1 E1 enzyme". FASEB J. 15 (10): 1825–7. doi: 10.1096/fj.00-0818fje . PMID   11481243. S2CID   40471133.
• Tatham MH, Kim S, Yu B, Jaffray E, Song J, Zheng J, Rodriguez MS, Hay RT, Chen Y (2003). "Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation". Biochemistry. 42 (33): 9959–69. doi:10.1021/bi0345283. PMID   12924945.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, Nakayama KI, Yamamoto H, Kikuchi A, Morohashi K (2004). "Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9". Mol. Endocrinol. 18 (10): 2451–62. doi: 10.1210/me.2004-0173 . PMID   15192080.
• Salinas S, Briançon-Marjollet A, Bossis G, Lopez MA, Piechaczyk M, Jariel-Encontre I, Debant A, Hipskind RA (2004). "SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1". J. Cell Biol. 165 (6): 767–73. doi:10.1083/jcb.200310136. PMC   2172397 . PMID   15210726.
• Lin JY, Ohshima T, Shimotohno K (2004). "Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53". FEBS Lett. 573 (1–3): 15–8. doi: 10.1016/j.febslet.2004.07.059 . PMID   15327968. S2CID   34290197.
• Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S (2004). "A mechanism for inhibiting the SUMO pathway". Mol. Cell. 16 (4): 549–61. doi: 10.1016/j.molcel.2004.11.007 . PMID   15546615.
• Lois LM, Lima CD (2005). "Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1". EMBO J. 24 (3): 439–51. doi:10.1038/sj.emboj.7600552. PMC   548657 . PMID   15660128.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Klenk C, Humrich J, Quitterer U, Lohse MJ (2006). "SUMO-1 controls the protein stability and the biological function of phosducin". J. Biol. Chem. 281 (13): 8357–64. doi: 10.1074/jbc.M513703200 . PMID   16421094.
• Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB (2006). "A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers". Arch. Biochem. Biophys. 453 (1): 70–4. doi:10.1016/j.abb.2006.03.002. PMID   16620772.
• Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X (2006). "Ubc9 interacts with SOX4 and represses its transcriptional activity". Biochem. Biophys. Res. Commun. 344 (3): 727–34. doi:10.1016/j.bbrc.2006.03.194. PMID   16631117.

External links

• SAE1 human gene location in the UCSC Genome Browser .
• SAE1 human gene details in the UCSC Genome Browser .