SEC22B

Last updated
SEC22B
Protein SEC22B PDB 1ifq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SEC22B , ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein
External IDs OMIM: 604029; MGI: 1338759; HomoloGene: 3597; GeneCards: SEC22B; OMA:SEC22B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004892

NM_011342

RefSeq (protein)

NP_004883

NP_035472

Location (UCSC) Chr 1: 120.15 – 120.18 Mb Chr 3: 97.81 – 97.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene. [5] [6] [7]

Contents

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes [8] and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies. [9] This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. [7] SEC22B has been shown to interact with syntaxin 18 [10] and syntaxin 5. [11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000265808 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027879 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hay JC, Chao DS, Kuo CS, Scheller RH (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
  6. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". The Journal of Biological Chemistry. 281 (7): 4495–506. doi: 10.1074/jbc.M509715200 . PMID   16354670.
  7. 1 2 "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".
  8. Lo, Richard W.; Li, Ling; Pluthero, Fred G.; Leung, Richard; Eto, Koji; Kahr, Walter H. A. (2020-08-06). "The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis". Blood. 136 (6): 715–725. doi:10.1182/blood.2019004276. ISSN   0006-4971.
  9. Ellie Karampini; Petra E. Bürgisser; Jenny Olins; Aat A. Mulder; Carolina R. Jost; Dirk Geerts; Jan Voorberg; Ruben Bierings (2020-03-26). "Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport". Haematologica. 106 (4): 1138–1147. doi:10.3324/haematol.2019.242727. ISSN   1592-8721. PMC   8018124 . PMID   32336681.
  10. Hatsuzawa, Kiyotaka; Hirose, Hidenori; Tani, Katsuko; Yamamoto, Akitsugu; Scheller, Richard H.; Tagaya, Mitsuo (May 2000). "Syntaxin 18, a SNAP Receptor That Functions in the Endoplasmic Reticulum, Intermediate Compartment, and cis-Golgi Vesicle Trafficking". Journal of Biological Chemistry. 275 (18): 13713–13720. doi: 10.1074/jbc.275.18.13713 . ISSN   0021-9258. PMID   10788491.
  11. Kat, Marije; Karampini, Ellie; Hoogendijk, Arie J.; Bürgisser, Petra E.; Mulder, Aat A.; Alphen, Floris P. J. van; Olins, Jenny; Geerts, Dirk; Biggelaar, Maartje van den; Margadant, Coert; Voorberg, Jan; Bierings, Ruben (2022-01-27). "Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture". Haematologica. 107 (8): 1827–1839. doi:10.3324/haematol.2021.280121. ISSN   1592-8721. PMC   9335113 . PMID   35081689.

Further reading