SEC22B

Last updated
SEC22B
Protein SEC22B PDB 1ifq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SEC22B , ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein
External IDs OMIM: 604029 MGI: 1338759 HomoloGene: 3597 GeneCards: SEC22B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004892

NM_011342

RefSeq (protein)

NP_004883

NP_035472

Location (UCSC) Chr 1: 120.15 – 120.18 Mb Chr 3: 97.81 – 97.83 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene. [5] [6] [7]

Contents

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. [7] SEC22B has been shown to interact with syntaxin 18.

Related Research Articles

The Coat Protein Complex II, or COPII, is a group of proteins that facilitate the formation of vesicles to transport proteins from the endoplasmic reticulum to the Golgi apparatus or endoplasmic-reticulum–Golgi intermediate compartment. This process is termed anterograde transport, in contrast to the retrograde transport associated with the COPI complex. COPII is assembled in two parts: first an inner layer of Sar1, Sec23, and Sec24 forms; then the inner coat is surrounded by an outer lattice of Sec13 and Sec31.

<span class="mw-page-title-main">VAMP2</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

<span class="mw-page-title-main">USO1</span> Protein-coding gene in the species Homo sapiens

General vesicular transport factor p115 is a protein that in humans is encoded by the USO1 gene.

<span class="mw-page-title-main">STX6</span> Protein-coding gene in the species Homo sapiens

Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.

<span class="mw-page-title-main">NAPA (gene)</span> Protein-coding gene in the species Homo sapiens

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

<span class="mw-page-title-main">SCAMP1</span> Protein-coding gene in the species Homo sapiens

Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene.

<span class="mw-page-title-main">STX5</span> Protein-coding gene in the species Homo sapiens

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.

<span class="mw-page-title-main">GOSR1</span> Protein-coding gene in the species Homo sapiens

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.

<span class="mw-page-title-main">ZW10</span>

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.

<span class="mw-page-title-main">BET1L</span> Protein-coding gene in the species Homo sapiens

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

<span class="mw-page-title-main">VAMP4</span> Protein-coding gene in the species Homo sapiens

Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.

<span class="mw-page-title-main">VAPA</span> Protein-coding gene in humans

VAMP-Associated Protein A is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes.

<span class="mw-page-title-main">BET1</span> Protein-coding gene in the species Homo sapiens

BET1 homolog is a protein that in humans is encoded by the BET1 gene.

<span class="mw-page-title-main">SCFD1</span> Protein-coding gene in the species Homo sapiens

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.

<span class="mw-page-title-main">USE1</span> Protein-coding gene in the species Homo sapiens

Uncharacterized hematopoietic stem/progenitor cells protein MDS032, also known as MDS032, is a protein which in humans is encoded by the MDS032 gene.

<span class="mw-page-title-main">RINT1</span> Protein-coding gene in the species Homo sapiens

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.

<span class="mw-page-title-main">GOSR2</span> Protein-coding gene in the species Homo sapiens

Golgi SNAP receptor complex member 2 is a protein that in humans is encoded by the GOSR2 gene.

<span class="mw-page-title-main">SEC61G</span>

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.

<span class="mw-page-title-main">SEC22A</span> Protein-coding gene in the species Homo sapiens

Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.

<span class="mw-page-title-main">SEC23IP</span> Protein-coding gene in the species Homo sapiens

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000265808 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027879 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hay JC, Chao DS, Kuo CS, Scheller RH (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi: 10.1016/S0092-8674(00)80191-9 . PMID   9094723. S2CID   8682509.
  6. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". The Journal of Biological Chemistry. 281 (7): 4495–506. doi: 10.1074/jbc.M509715200 . PMID   16354670.
  7. 1 2 "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".

Further reading