SEC23IP

SEC23IP
Identifiers
Aliases	SEC23IP , P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
External IDs	OMIM: 617852 MGI: 2450915 HomoloGene: 38288 GeneCards: SEC23IP
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.11-q26.12 Start 119,892,730 bp [1] End 119,944,657 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F3|7 70.51 cM Start 128,346,667 bp [2] End 128,386,560 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium secondary oocyte Achilles tendon islet of Langerhans monocyte smooth muscle tissue thymus tibia rectum stomach Top expressed in spermatid seminiferous tubule spermatocyte calvaria cumulus cell yolk sac pituitary gland dermis secondary oocyte primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding phospholipase activity RNA binding Cellular component cytoplasm ER to Golgi transport vesicle membrane cytosol endoplasmic reticulum membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment Golgi membrane COPII-coated ER to Golgi transport vesicle Golgi apparatus intracellular membrane-bounded organelle Biological process COPII vesicle coating intracellular protein transport Golgi organization endoplasmic reticulum to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11196 207352 Ensembl ENSG00000107651 ENSMUSG00000055319 UniProt Q9Y6Y8 Q6NZC7 RefSeq (mRNA) NM_007190 NM_001029982 RefSeq (protein) NP_009121 n/a Location (UCSC) Chr 10: 119.89 – 119.94 Mb Chr 7: 128.35 – 128.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene. ^{[5] [6]}

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107651 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055319 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi: 10.1074/jbc.274.29.20505 . PMID   10400679.
6. "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading

• Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi: 10.1074/jbc.M600322200 . PMID   16510448.
• Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi: 10.1074/jbc.M409673200 . PMID   15623529.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein". Biochem. Biophys. Res. Commun. 279 (1): 144–9. doi:10.1006/bbrc.2000.3846. PMID   11112430.