SELT

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SELENOT
Identifiers
Aliases	SELENOT , SELT, selenoprotein T
External IDs	OMIM: 607912; MGI: 1916477; HomoloGene: 32304; GeneCards: SELENOT; OMA:SELENOT - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.1 Start 150,602,875 bp [1] End 150,630,436 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 D Start 58,484,057 bp [2] End 58,500,554 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right adrenal gland right adrenal cortex internal globus pallidus left adrenal gland monocyte beta cell stromal cell of endometrium left adrenal cortex prefrontal cortex Top expressed in olfactory epithelium iris median eminence sciatic nerve primitive streak Epithelium of choroid plexus barrel cortex Region I of hippocampus proper vestibular membrane of cochlear duct endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function selenium binding thioredoxin-disulfide reductase activity oxidoreductase activity Cellular component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane Biological process selenocysteine incorporation positive regulation of cytosolic calcium ion concentration positive regulation of growth hormone secretion cellular oxidant detoxification response to glucose pancreas development insulin secretion involved in cellular response to glucose stimulus glucose homeostasis cell redox homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51714 69227 Ensembl ENSG00000198843 ENSMUSG00000075700 UniProt P62341 P62342 RefSeq (mRNA) NM_016275 NM_001040396 NM_026997 RefSeq (protein) NP_057359 NP_001035486 Location (UCSC) Chr 3: 150.6 – 150.63 Mb Chr 3: 58.48 – 58.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene. ^{[5] [6] [7]}

Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. ^[7]

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

See also

• selenoprotein

References

1. GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi: 10.1074/jbc.274.48.33888 . PMID   10567350.
6. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes" . Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID   12775843. S2CID   10363908.
7. "Entrez Gene: SELT selenoprotein T".

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.