| SELENOT | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SELENOT , SELT, selenoprotein T | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607912 MGI: 1916477 HomoloGene: 32304 GeneCards: SELENOT | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene. [5] [6] [7]
The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [7]
Selenoprotein T contains a selenocysteine (Sec) residue at its active site.
Selenocysteine is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur.
In molecular biology, a stop codon is a codon that signals the termination of the translation process of the current protein. Most codons in messenger RNA correspond to the addition of an amino acid to a growing polypeptide chain, which may ultimately become a protein; stop codons signal the termination of this process by binding release factors, which cause the ribosomal subunits to disassociate, releasing the amino acid chain.
In biology, the SECIS element is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif directs the cell to translate UGA codons as selenocysteines. SECIS elements are thus a fundamental aspect of messenger RNAs encoding selenoproteins, proteins that include one or more selenocysteine residues.
In molecular biology a selenoprotein is any protein that includes a selenocysteine amino acid residue. Among functionally characterized selenoproteins are five glutathione peroxidases (GPX) and three thioredoxin reductases, (TrxR/TXNRD) which both contain only one Sec. Selenoprotein P is the most common selenoprotein found in the plasma. It is unusual because in humans it contains 10 Sec residues, which are split into two domains, a longer N-terminal domain that contains 1 Sec, and a shorter C-terminal domain that contains 9 Sec. The longer N-terminal domain is likely an enzymatic domain, and the shorter C-terminal domain is likely a means of safely transporting the very reactive selenium atom throughout the body.
Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.
Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.
Selenoprotein S, also known as SELS, is a human gene.
Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.
40S ribosomal protein S17 is a protein that in humans is encoded by the RPS17 gene.
SECIS-binding protein 2 is a protein that in humans is encoded by the SECISBP2 gene.
15 kDa selenoprotein is a protein that in humans is encoded by the SEP15 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.
39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.
Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.
39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.
Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.
Type II iodothyronine deiodinase is an enzyme that in humans is encoded by the DIO2 gene.
28S ribosomal protein S33, mitochondrial is a protein that in humans is encoded by the MRPS33 gene.
Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.
Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.
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