SEMA4C

Last updated
SEMA4C
Identifiers
Aliases SEMA4C , M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs OMIM: 604462 MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017789

NM_001126047
NM_001304329
NM_001304330

RefSeq (protein)

NP_060259

NP_001119519
NP_001291258
NP_001291259

Location (UCSC) Chr 2: 96.86 – 96.87 Mb Chr 1: 36.59 – 36.6 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene. [5] [6]

Contents

Interactions

SEMA4C has been shown to interact with DLG4. [7]

Related Research Articles

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GIPC PDZ domain containing family, member 1 (GIPC1) is a protein that in humans is encoded by the GIPC1 gene. GIPC was originally identified as it binds specifically to the C terminus of RGS-GAIP, a protein involved in the regulation of G protein signaling. GIPC is an acronym for "GAIP Interacting Protein C-terminus". RGS proteins are "Regulators of G protein Signaling" and RGS-GAIP is a "GTPase Activator protein for Gαi/Gαq", which are two major subtypes of Gα proteins. The human GIPC1 molecule is 333 amino acids or about 36 kDa in molecular size and consists of a central PDZ domain, a compact protein module which mediates specific protein-protein interactions. The RGS-GAIP protein interacts with this domain and many other proteins interact here or at other parts of the GIPC1 molecule. As a result, GIPC1 was independently discovered by several other groups and has a variety of alternate names, including synectin, C19orf3, RGS19IP1 and others. The GIPC1 gene family in mammals consisting of three members, so the first discovered, originally named GIPC, is now generally called GIPC1, with the other two being named GIPC2 and GIPC3. The three human proteins are about 60% identical in protein sequence. GIPC1 has been shown to interact with a variety of other receptor and cytoskeletal proteins including the GLUT1 receptor, ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4, SEMA4C/semaphorin-4 and HTLV-I Tax. The general function of GIPC family proteins therefore appears to be mediating specific interactions between proteins involved in G protein signaling and membrane translocation.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168758 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026121 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi: 10.1016/0014-5793(95)00850-9 . PMID   7656991.
  6. "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
  7. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi: 10.1074/jbc.M009051200 . PMID   11134026.

Further reading