SFRS6

SRSF6
Identifiers
Aliases	SRSF6 , B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, serine and arginine rich splicing factor 6
External IDs	OMIM: 601944 MGI: 1915246 HomoloGene: 110783 GeneCards: SRSF6
Gene location (Human)
Chr.	Chromosome 20 (human)
End	43,466,046 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	162,779,041 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; germinal epithelium; ; left adrenal gland; ; tibia; ; minor salivary gland; ; gallbladder; ; parietal pleura;
	Top expressed in
	medullary collecting duct; ; abdominal wall; ; renal corpuscle; ; endocardial cushion; ; somite; ; superior cervical ganglion; ; dermis; ; atrioventricular valve; ; primitive streak; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ; nucleic acid binding ; pre-mRNA binding ;
Cellular component	nuclear speck ; nucleus ; nucleoplasm ;
Biological process	mRNA splicing, via spliceosome ; termination of RNA polymerase II transcription ; negative regulation of keratinocyte differentiation ; positive regulation of epithelial cell proliferation involved in lung morphogenesis ; mRNA processing ; negative regulation of cell death ; regulation of alternative mRNA splicing, via spliceosome ; mRNA export from nucleus ; negative regulation of mRNA splicing, via spliceosome ; regulation of wound healing ; mRNA splice site selection ; regulation of keratinocyte proliferation ; alternative mRNA splicing, via spliceosome ; mRNA 3'-end processing ; negative regulation of gene expression ; RNA splicing ; response to insulin ; RNA export from nucleus ; negative regulation of type B pancreatic cell apoptotic process ; mRNA cis splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	6431
	67996
	ENSG00000124193
	ENSMUSG00000016921
	Q13247
	Q3TWW8
	NM_006275
	NM_026499
	NP_006266
	NP_080775
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 28, 2023

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.^[5]^[6]

Function

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[6]

Related Research Articles

SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are "S" and "R" respectively. SR proteins are ~200-600 amino acids in length and composed of two domains, the RNA recognition motif (RRM) region and the RS domain. SR proteins are more commonly found in the nucleus than the cytoplasm, but several SR proteins are known to shuttle between the nucleus and the cytoplasm.

In molecular biology, an exonic splicing enhancer (ESE) is a DNA sequence motif consisting of 6 bases within an exon that directs, or enhances, accurate splicing of heterogeneous nuclear RNA (hnRNA) or pre-mRNA into messenger RNA (mRNA).

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene. MDS-associated splicing factor SRSF2 affects the expression of Class III and Class IV isoforms and perturbs granulopoiesis and SRSF2 P95H promotes Class IV splicing by binding to key ESE sequences in CSF3R exon 17, and that SRSF2, when mutated, contributes to dysgranulopoiesis.

Splicing factor U2AF 65 kDa subunit is a protein that in humans is encoded by the U2AF2 gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.

Splicing factor, arginine/serine-rich 9, also known as SFRS9, is a human gene encoding an SR protein involved in splice site selection in alternative splicing.

Splicing factor, arginine/serine-rich 5 is a protein that in humans is encoded by the SFRS5 gene.

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.

FUS-interacting serine-arginine-rich protein 1 is a protein that in humans is encoded by the SFRS13A gene.

Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

ADP-ribosylation-like factor 6 interacting protein 4 (ARL6IP4), also called SRp25 is the product of the ARL6IP4 gene located on chromosome 12q24. 31. Its function is unknown.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124193 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016921 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (September 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". The EMBO Journal. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518 . PMID 7556075.
1 2 "Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6".

Zahler AM, Lane WS, Stolk JA, Roth MB (May 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes & Development. 6 (5): 837–47. doi: 10.1101/gad.6.5.837 . PMID 1577277.
Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA (September 1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer". Molecular and Cellular Biology. 15 (9): 4898–907. doi:10.1128/MCB.15.9.4898. PMC 230736 . PMID 7651409.
Gui JF, Lane WS, Fu XD (June 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-11.
Nagel RJ, Lancaster AM, Zahler AM (January 1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55". RNA. 4 (1): 11–23. PMC 1369592 . PMID 9436904.
Liu HX, Zhang M, Krainer AR (July 1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins". Genes & Development. 12 (13): 1998–2012. doi:10.1101/gad.12.13.1998. PMC 316967 . PMID 9649504.
Lemaire R, Winne A, Sarkissian M, Lafyatis R (March 1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation". European Journal of Immunology. 29 (3): 823–37. doi: 10.1002/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C . PMID 10092085. S2CID 23297953.
Paillard F (May 1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Human Gene Therapy. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
Barnard DC, Patton JG (May 2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Molecular and Cellular Biology. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584 . PMID 10757789.
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM (August 2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1". Molecular Cell. 6 (2): 307–16. doi: 10.1016/S1097-2765(00)00031-9 . PMID 10983978.
Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW (August 2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Tran Q, Coleman TP, Roesser JR (January 2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1625 (2): 141–52. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
Tran Q, Roesser JR (February 2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing". Biochemistry. 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
Lai MC, Lin RI, Tarn WY (May 2003). "Differential effects of hyperphosphorylation on splicing factor SRp55". The Biochemical Journal. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMC 1223332 . PMID 12549978.
Pind MT, Watson PH (May 2003). "SR protein expression and CD44 splicing pattern in human breast tumours". Breast Cancer Research and Treatment. 79 (1): 75–82. doi:10.1023/A:1023338718974. PMID 12779084. S2CID 24657578.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616 . PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124193 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016921 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7556075-5] Screaton GR, Cáceres JF, Mayeda A, Bell MV, Plebanski M, Jackson DG, Bell JI, Krainer AR (September 1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors". The EMBO Journal. 14 (17): 4336–49. doi:10.1002/j.1460-2075.1995.tb00108.x. PMC 394518 . PMID 7556075.

[entrez-6] 1 2 "Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6".

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SFRS6

Contents

Function

Related Research Articles

References

Further reading