SHC2

SHC2
Identifiers
Aliases	SHC2 , SCK, SHCB, SLI, SHC adaptor protein 2
External IDs	OMIM: 605217; MGI: 106180; HomoloGene: 19127; GeneCards: SHC2; OMA:SHC2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 416,589 bp [1] End 461,033 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 79,453,885 bp [2] End 79,473,752 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas anterior pituitary right lobe of liver right uterine tube gastric mucosa apex of heart right frontal lobe left lobe of thyroid gland right lobe of thyroid gland amygdala Top expressed in superior cervical ganglion lumbar spinal ganglion primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell neural tube genital tubercle muscle of thigh tail of embryo humerus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding receptor tyrosine kinase binding Cellular component cytosol plasma membrane cellular component Biological process Ras protein signal transduction vascular endothelial growth factor receptor signaling pathway MAPK cascade transmembrane receptor protein tyrosine kinase signaling pathway intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25759 216148 Ensembl ENSG00000129946 ENSMUSG00000020312 UniProt P98077 Q8BMC3 RefSeq (mRNA) NM_012435 NM_001387056 NM_001024539 RefSeq (protein) NP_036567 NP_001019710 Location (UCSC) Chr 19: 0.42 – 0.46 Mb Chr 10: 79.45 – 79.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene. ^{[5] [6] [7]}

Interactions

SHC2 has been shown to interact with Kinase insert domain receptor. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000129946 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020312 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID   7527937.
6. Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID   9507002.
7. "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
8. Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2). England: 501–9. doi:10.1042/0264-6021:3470501. ISSN   0264-6021. PMC   1220983 . PMID   10749680.

Further reading

• Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID   16368877.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi: 10.1074/jbc.M111659200 . PMID   12006576.
• Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC   1220983 . PMID   10749680.
• Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID   8760305.