SHC2

SHC2
Identifiers
Aliases	SHC2 , SCK, SHCB, SLI, SHC adaptor protein 2
External IDs	OMIM: 605217 MGI: 106180 HomoloGene: 19127 GeneCards: SHC2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	460,996 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding ; • receptor tyrosine kinase binding ; • Ras guanyl-nucleotide exchange factor activity ;
Cellular component	• cytosol ; • cell membrane ; • cellular component ;
Biological process	• Ras protein signal transduction ; • vascular endothelial growth factor receptor signaling pathway ; • MAPK cascade ; • activation of MAPK activity ; • transmembrane receptor protein tyrosine kinase signaling pathway ; • GO:0007243 intracellular signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	25759
	216148
	ENSG00000129946
	ENSMUSG00000020312
	P98077
	Q8BMC3
	NM_012435
	NM_001024539
	NP_036567
	NP_001019710
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 18, 2020

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.^[4]^[5]^[6]

Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.^[7]

Related Research Articles

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains.

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit.

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Kinase insert domain receptor also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309. KDR is also known as Flk1.

Bradykinin receptor B₂ is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.

Interleukin 9 receptor (IL9R) also known as CD129 is a type I cytokine receptor. IL9R also denotes its human gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID 7527937.
↑ Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID 9507002.
↑ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".
↑ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983 . PMID 10749680.

Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi: 10.1074/jbc.M111659200 . PMID 12006576.
Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983 . PMID 10749680.
Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129946 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7527937-4] Kavanaugh WM; Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science. 266 (5192): 1862–5. Bibcode:1994Sci...266.1862K. doi:10.1126/science.7527937. PMID 7527937.

[pmid9507002-5] Nakamura T; Muraoka S; Sanokawa R; Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem. 273 (12): 6960–7. doi: 10.1074/jbc.273.12.6960 . PMID 9507002.

[entrez-6] "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2".

[pmid10749680-7] Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983 . PMID 10749680.

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SHC2

Contents

Interactions

Related Research Articles

References

Further reading