SMAP1

SMAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRR
Identifiers
Aliases	SMAP1 , SMAP-1, small ArfGAP 1
External IDs	OMIM: 611372 MGI: 2138261 HomoloGene: 134676 GeneCards: SMAP1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q13 Start 70,667,776 bp [1] End 70,862,011 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A5 Start 23,883,927 bp [2] End 23,961,398 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa cavity of mouth pons duodenum islet of Langerhans ganglionic eminence superior vestibular nucleus superior surface of tongue sural nerve rectum Top expressed in blood seminiferous tubule spermatid superior frontal gyrus calvaria ascending aorta cerebellar cortex aortic valve fossa barrel cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin binding metal ion binding GTPase activator activity Cellular component cytoplasm plasma membrane membrane Biological process positive regulation of GTPase activity regulation of clathrin-dependent endocytosis positive regulation of erythrocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60682 98366 Ensembl ENSG00000112305 ENSMUSG00000026155 UniProt Q8IYB5 Q91VZ6 RefSeq (mRNA) NM_001044305 NM_001281439 NM_001281440 NM_021940 NM_001290683 NM_028534 NM_001357395 RefSeq (protein) NP_001037770 NP_001268368 NP_001268369 NP_068759 NP_001277612 NP_082810 NP_001344324 Location (UCSC) Chr 6: 70.67 – 70.86 Mb Chr 1: 23.88 – 23.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Stromal membrane-associated protein 1 is a protein that in humans is encoded by the SMAP1 gene. ^{[5] [6] [7]}

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112305 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026155 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sato Y, Hong HN, Yanai N, Obinata M (Sep 1998). "Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment". J Biochem. 124 (1): 209–16. doi:10.1093/oxfordjournals.jbchem.a022082. PMID   9644265.
6. Marcos I, Borrego S, Rodriguez de Cordoba S, Galan JJ, Antinolo G (Jul 2002). "Cloning, characterization and chromosome mapping of the human SMAP1 gene". Gene. 292 (1–2): 167–71. doi:10.1016/S0378-1119(02)00645-5. PMID   12119110.
7. "SMAP1 small ArfGAP 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-05-07.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis". Mol. Biol. Cell. 16 (4): 1617–28. doi:10.1091/mbc.E04-08-0683. PMC   1073646 . PMID   15659652.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID   16273301.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.