SMIM11

SMIM11
Identifiers
Aliases	SMIM11 , C21orf51, FAM165B, small integral membrane protein 11, SMIM11B, SMIM11A, small integral membrane protein 11A
External IDs	HomoloGene: 129857; GeneCards: SMIM11; OMA:SMIM11 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.11 Start 34,375,480 bp [1] End 34,416,961 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach muscle of thigh fundus nucleus accumbens prefrontal cortex putamen gastrocnemius muscle islet of Langerhans anterior cingulate cortex amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component membrane integral component of membrane cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54065 n/a Ensembl ENSG00000205670 n/a UniProt P58511 n/a RefSeq (mRNA) NM_058182 NM_001376899 n/a RefSeq (protein) NP_478062 NP_001363828 n/a Location (UCSC) Chr 21: 34.38 – 34.42 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene. ^{[3] [4]}

Gene

Locus

SMIM11 is located on the plus strand of chromosome 21 and has 4 exons. ^[4]

Expression of SMIM11A in human tissue samples

Expression

The expression of SMIM11 is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues. ^[4]

mRNA

There are no known transcript variants or isoforms of SMIM11. ^[5]

Protein

The SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9. ^[6] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells. ^{[7] [8]}

Domains, Motifs, and Post-translational Modifications

SMIM11 contains a transmembrane domain. ^[9] The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine ^{[10] [11]}

Secondary Structure and Tertiary Structure

The protein is composed mostly of alpha-helices. ^[12] The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell. ^[13]

Tertiary Structure of SMIM11

Quaternary Structure and Protein Interactions

Experimentally-determined protein interactions for SMIM11 have not yet been identified. ^[14]

Concenptual translation of SMIM11

Homology and Evolution

Paralogs

No paralogs or paralogous domains exist for SMIM11

Orthologs

SMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish. ^[15]

Ortholog Table of SMIM11

References

1. GRCh38: Ensembl release 89: ENSG00000205670 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "P58511 · SIM11_HUMAN". www.uniprot.org. UniProt . Retrieved 2022-12-23.
4. "SMIM11 small integral membrane protein 11 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine . Retrieved 2022-12-23.
5. "SMIM11A Protein Coding". genecards.org.
6. "Compute pI/Mw Tool Expasy". expasy.org.
7. "PSORT II Server". psort.hgc.jp.
8. "Immunohistochemistry of SMIM11A: The Human Protein Atlas". proteinatlas.org.
9. "Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA". ncbi.nlm.nih.gov. NCBI (National Center for Biotechnology Information). 6 July 2019.
10. "iPTMnet Report for P58511 (SMIM11A)". research.bioinformatics.udel.edu.
11. "NetPhos 3.1 Server". cbs.dtu.dk.
12. "Phyre2 Results". sbg.bio.ic.ac.uk.
13. "TMHHM Server". cbs.dtu.dk.
14. "STRING FAM165B". string-db.org.
15. "NCBI Protein Blast". blast.ncbi.nlm.nih.gov.