SNAPC1

SNAPC1
Identifiers
Aliases	SNAPC1 , PTFgamma, SNAP43, small nuclear RNA activating complex polypeptide 1
External IDs	OMIM: 600591; MGI: 1922877; HomoloGene: 2317; GeneCards: SNAPC1; OMA:SNAPC1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.2 Start 61,762,420 bp [1] End 61,796,428 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 74,011,255 bp [2] End 74,035,740 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle cartilage tissue oocyte secondary oocyte sperm bronchial epithelial cell Achilles tendon tail of epididymis caput epididymis mucosa of paranasal sinus Top expressed in otolith organ utricle supraoptic nucleus zygote secondary oocyte pituitary gland hand neural layer of retina paraventricular nucleus of hypothalamus cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding Cellular component snRNA-activating protein complex nucleus nucleoplasm nucleolus Biological process regulation of transcription, DNA-templated transcription, DNA-templated snRNA transcription by RNA polymerase III snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6617 75627 Ensembl ENSG00000023608 ENSMUSG00000021113 UniProt Q16533 Q8K0S9 RefSeq (mRNA) NM_003082 NM_178392 RefSeq (protein) NP_003073 NP_848479 Location (UCSC) Chr 14: 61.76 – 61.8 Mb Chr 12: 74.01 – 74.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene. ^{[5] [6]}

Interactions

SNAPC1 has been shown to interact with SNAPC4, ^[7] SNAPC3 ^{[7] [8]} and Retinoblastoma protein. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000023608 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021113 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maeng JH, Yoon JB (September 1998). "The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR". J Biochem. 124 (1): 23–7. doi:10.1093/oxfordjournals.jbchem.a022085. PMID   9644240.
6. "Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa".
7. Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7). United States: 5027–35. doi: 10.1074/jbc.M009301200 . ISSN   0021-9258. PMID   11056176.
8. Henry RW, Ma B, Sadowski C L, Kobayashi R, Hernandez N (Dec 1996). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24). ENGLAND: 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. ISSN   0261-4189. PMC   452539 . PMID   9003788.
9. Hirsch HA, Gu L, Henry R W (Dec 2000). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24). UNITED STATES: 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. ISSN   0270-7306. PMC   102176 . PMID   11094070.

Further reading

• Henry RW, Sadowski CL, Kobayashi R, Hernandez N (1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID   7715707. S2CID   4325527.
• Yoon JB, Roeder RG (1996). "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein". Mol. Cell. Biol. Advances in Molecular and Cell Biology. 16 (1): 1–9. doi:10.1016/S1569-2558(08)60061-2. ISBN   978-0-7623-0143-0. PMC   230972 . PMID   8524284.
• Henry RW, Ma B, Sadowski CL, et al. (1997). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24): 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. PMC   452539 . PMID   9003788.
• Ma B, Hernandez N (2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7): 5027–35. doi: 10.1074/jbc.M009301200 . PMID   11056176.
• Hirsch HA, Gu L, Henry RW (2001). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC   102176 . PMID   11094070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hinkley CS, Hirsch HA, Gu L, et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". J. Biol. Chem. 278 (20): 18649–57. doi: 10.1074/jbc.M204247200 . PMID   12621023.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gu L, Esselman WJ, Henry RW (2005). "Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC". J. Biol. Chem. 280 (30): 27697–704. doi: 10.1074/jbc.M503206200 . PMID   15955816.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.