SNAPC4

SNAPC4
Identifiers
Aliases	SNAPC4 , PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
External IDs	OMIM: 602777; MGI: 2443935; HomoloGene: 2321; GeneCards: SNAPC4; OMA:SNAPC4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 136,375,567 bp [1] End 136,400,176 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 26,252,777 bp [2] End 26,270,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve endothelial cell right uterine tube paraflocculus of cerebellum right testis left testis right hemisphere of cerebellum frontal pole pancreatic ductal cell nasal epithelium Top expressed in superior frontal gyrus neural layer of retina primary visual cortex tail of embryo genital tubercle lumbar subsegment of spinal cord spermatocyte yolk sac ventricular zone cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm snRNA-activating protein complex Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated snRNA transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase II snRNA transcription by RNA polymerase II cell differentiation snRNA transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6621 227644 Ensembl ENSG00000165684 ENSMUSG00000036281 UniProt Q5SXM2 Q8BP86 RefSeq (mRNA) NM_003086 NM_001394201 NM_001394202 NM_001394203 NM_001290419 NM_172339 RefSeq (protein) NP_003077 NP_001277348 NP_758842 NP_001393660 NP_001393661 NP_001393662 NP_001393663 NP_001393664 NP_001393665 NP_001393666 NP_001393667 NP_001393668 Location (UCSC) Chr 9: 136.38 – 136.4 Mb Chr 2: 26.25 – 26.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene. ^{[5] [6]}

Interactions

SNAPC4 has been shown to interact with SNAPC1, ^[7] POU2F1 ^{[5] [8]} and SNAPC2. ^{[5] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000165684 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036281 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC   121507 . PMID   9418884.
6. "Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa".
7. Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi: 10.1074/jbc.M009301200 . PMID   11056176.
8. Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. Bibcode:2002AcCrD..58..511H. doi:10.1107/S0907444901021461. PMID   11856838.

Further reading

• Henry RW, Sadowski CL, Kobayashi R, Hernandez N (April 1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID   7715707. S2CID   4325527.
• Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi: 10.1074/jbc.M009301200 . PMID   11056176.
• Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. Bibcode:2002AcCrD..58..511H. doi:10.1107/S0907444901021461. PMID   11856838.
• Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal of Biological Chemistry. 278 (20): 18649–57. doi: 10.1074/jbc.M204247200 . PMID   12621023.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gu L, Esselman WJ, Henry RW (July 2005). "Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC". The Journal of Biological Chemistry. 280 (30): 27697–704. doi: 10.1074/jbc.M503206200 . PMID   15955816.
• Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW (September 2007). "The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III". The Journal of Biological Chemistry. 282 (38): 27887–96. doi: 10.1074/jbc.M702269200 . PMID   17670747.