SOSTDC1

Last updated
SOSTDC1
Identifiers
Aliases SOSTDC1 , ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDs OMIM: 609675; MGI: 1913292; HomoloGene: 9154; GeneCards: SOSTDC1; OMA:SOSTDC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015464

NM_025312

RefSeq (protein)

NP_056279

NP_079588

Location (UCSC) Chr 7: 16.46 – 16.53 Mb Chr 12: 36.36 – 36.37 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. [5]

Contents

Function

This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [5]

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry. [6] [7] [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171243 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036169 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
  6. Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC   7880588 . PMID   33579703.
  7. Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC   9931762 . PMID   36819612.
  8. "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.

Further reading