Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. [5]
This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [5]
Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry. [6] [7] [8]