SS18L1

Last updated • a couple of secsFrom Wikipedia, The Free Encyclopedia
SS18L1
Identifiers
Aliases SS18L1 , CREST, LP2261, nBAF chromatin remodeling complex subunit, SS18L1 subunit of BAF chromatin remodeling complex, SMARCL2
External IDs OMIM: 606472; MGI: 2444061; HomoloGene: 9191; GeneCards: SS18L1; OMA:SS18L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301778
NM_015558
NM_198935

NM_178750

RefSeq (protein)

NP_001288707
NP_945173

NP_848865

Location (UCSC) Chr 20: 62.14 – 62.18 Mb Chr 2: 179.68 – 179.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SS18-like protein 1 is a protein that in humans is encoded by the SS18L1 gene. [5]

Contents

Function

Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene is fused in-frame to the 3-prime end of the SSX1, SSX2, or SSX4 gene. The SS18L1 gene is homologous to SS18. [5]

Interactions

SS18L1 has been shown to interact with CREB-binding protein. [6] Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex. [7]

Related Research Articles

<span class="mw-page-title-main">Synovial sarcoma</span> Medical condition

A synovial sarcoma is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths. It is a type of soft-tissue sarcoma.

<span class="mw-page-title-main">SMARCB1</span> Protein-coding gene in the species Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

<span class="mw-page-title-main">Tyrosine-protein kinase Yes</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

<span class="mw-page-title-main">SMARCA2</span> Protein-coding gene in the species Homo sapiens

Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene.

<span class="mw-page-title-main">ARID1A</span> Protein-coding gene in humans

AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.

<span class="mw-page-title-main">SMARCE1</span> Protein-coding gene in the species Homo sapiens

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.

<span class="mw-page-title-main">SMARCC2</span> Protein-coding gene in the species Homo sapiens

SWI/SNF complex subunit SMARCC2 is a protein that in humans is encoded by the SMARCC2 gene.

<span class="mw-page-title-main">SSX2</span> Mammalian protein found in Homo sapiens

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.

<span class="mw-page-title-main">SS18</span> Protein-coding gene in the species Homo sapiens

Protein SSXT is a protein that in humans is encoded by the SS18 gene.

<span class="mw-page-title-main">ARID1B</span> Protein-coding gene in humans

AT-rich interactive domain-containing protein 1B is a protein that in humans is encoded by the ARID1B gene. ARID1B is a component of the human SWI/SNF chromatin remodeling complex.

<span class="mw-page-title-main">IL18BP</span> Protein-coding gene in the species Homo sapiens

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.

<span class="mw-page-title-main">CACNG2</span> Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, gamma subunit 2, also known as CACNG2 or stargazin is a protein that in humans is encoded by the CACNG2 gene.

<span class="mw-page-title-main">SSX1</span> Protein-coding gene in the species Homo sapiens

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.

<span class="mw-page-title-main">SSX4 (gene)</span> Protein-coding gene in the species Homo sapiens

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

<span class="mw-page-title-main">MLLT10</span> Protein-coding gene in the species Homo sapiens

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.

<span class="mw-page-title-main">ARHGDIG</span> Protein-coding gene in the species Homo sapiens

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.

<span class="mw-page-title-main">ZNF384</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 384 is a protein that in humans is encoded by the ZNF384 gene.

<span class="mw-page-title-main">RFWD2</span> Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.

<span class="mw-page-title-main">SSX5</span> Protein-coding gene in the species Homo sapiens

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.

<span class="mw-page-title-main">IRX2</span> Protein-coding gene in the species Homo sapiens

Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000184402 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039086 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1".
  6. Aizawa H, Hu SC, Bobb K, Balakrishnan K, Ince G, Gurevich I, Cowan M, Ghosh A (January 2004). "Dendrite development regulated by CREST, a calcium-regulated transcriptional activator". Science. 303 (5655): 197–202. Bibcode:2004Sci...303..197A. doi:10.1126/science.1089845. PMID   14716005. S2CID   20879721.
  7. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. Bibcode:2012PLoSO...733834M. doi: 10.1371/journal.pone.0033834 . PMC   3307773 . PMID   22442726.

Further reading