SSC4D

SSC4D
Identifiers
Aliases	SSC4D , S4D-SRCRB, SRCRB-S4D, SRCRB4D, scavenger receptor cysteine rich family member with 4 domains
External IDs	OMIM: 607639 MGI: 1924709 HomoloGene: 34137 GeneCards: SSC4D
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q11.23 Start 76,389,334 bp [1] End 76,409,697 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 135,989,065 bp [2] End 136,003,385 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland middle temporal gyrus deltoid muscle tibialis anterior muscle pons internal globus pallidus external globus pallidus saphenous vein pericardium ventral tegmental area Top expressed in otolith organ utricle stria vascularis secondary oocyte internal carotid artery submandibular gland morula external carotid artery seminal vesicula yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function scavenger receptor activity Cellular component membrane extracellular region external side of plasma membrane Biological process receptor-mediated endocytosis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 136853 109267 Ensembl ENSG00000146700 ENSMUSG00000029699 UniProt Q8WTU2 A1L0T3 RefSeq (mRNA) NM_080744 NM_001160366 RefSeq (protein) NP_542782 NP_001153838 Location (UCSC) Chr 7: 76.39 – 76.41 Mb Chr 5: 135.99 – 136 Mb PubMed search [3] [4]
Wikidata
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Scavenger receptor cysteine rich family member with 4 domains is a protein that in humans is encoded by the SSC4D gene. ^[5]

Function

The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.

References

1. GRCh38: Ensembl release 89: ENSG00000146700 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029699 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Scavenger receptor cysteine rich family member with 4 domains" . Retrieved 2016-09-05.

Further reading

• Padilla O, Pujana MA, López-de la Iglesia A, Gimferrer I, Arman M, Vilà JM, Places L, Vives J, Estivill X, Lozano F (2002). "Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23". Immunogenetics. 54 (9): 621–34. doi:10.1007/s00251-002-0507-z. PMID   12466895. S2CID   731351.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.