STAP1

STAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X1F, 3MAZ
Identifiers
Aliases	STAP1 , BRDG1, STAP-1, signal transducing adaptor family member 1
External IDs	OMIM: 604298 MGI: 1926193 HomoloGene: 8103 GeneCards: STAP1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,607,337 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,106,125 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• macrophage colony-stimulating factor receptor binding ; • transmembrane receptor protein tyrosine kinase adaptor activity ; • phosphotyrosine residue binding ; • receptor tyrosine kinase binding ; • GO:0001948 protein binding ; • phospholipid binding ; • protein kinase binding ; • signaling adaptor activity ;
Cellular component	• cytoplasm ; • mitochondrion ; • cell nucleus ; • nucleoplasm ; • intracellular membrane-bounded organelle ; • macromolecular complex ;
Biological process	• positive regulation of B cell receptor signaling pathway ; • positive regulation of phagocytosis, engulfment ; • transmembrane receptor protein tyrosine kinase signaling pathway ; • negative regulation of ruffle assembly ; • positive regulation of microglial cell mediated cytotoxicity ; • positive regulation of non-membrane spanning protein tyrosine kinase activity ; • negative regulation of microglial cell migration ; • positive regulation of gene expression ; • positive regulation of microglial cell activation ; • negative regulation of phosphorylation ; • cellular response to lipopolysaccharide ; • negative regulation of macrophage colony-stimulating factor signaling pathway ; • positive regulation of actin cytoskeleton reorganization ; • negative regulation of macrophage chemotaxis ; • response to bacterium ;
	Sources:Amigo / QuickGO
Orthologs
	26228
	56792
	ENSG00000035720
	ENSMUSG00000029254
	Q9ULZ2
	Q9JM90
	NM_012108 ; NM_001317769
	NM_019992 ; NM_001310639
	NP_001304698 ; NP_036240
	NP_001297568 ; NP_064376
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 16, 2020

Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.^[5]^[6]^[7]

Function

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.^[7]

Interactions

STAP1 has been shown to interact with C19orf2.^[8]

Related Research Articles

Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves, instead mediating specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MYD88, Grb2 and SHC1.

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is a member of the TEC family of kinases and is highly expressed in T cells.

CD5 is a cluster of differentiation expressed on the surface of T cells and in a subset of murine B cells known as B-1a. The expression of this receptor in human B cells has been a controversial topic and to date there is no consensus regarding the role of this receptor as a marker of human B cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.

The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.

Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.

Crk-like protein is a protein that in humans is encoded by the CRKL gene.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000035720 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029254 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397 . PMID 10518561.
↑ Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
1 2 "Entrez Gene: BRDG1 BCR downstream signaling 1".
↑ Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science . 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling". Annu. Rev. Immunol. 17 (1): 555–92. doi:10.1146/annurev.immunol.17.1.555. PMID 10358768.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, Mano H, Hirasawa H, Tokuhisa T (2002). "Isoform-dependent interaction of BRDG1 with Tec kinase". Biochem. Biophys. Res. Commun. 289 (2): 414–20. doi:10.1006/bbrc.2001.6008. PMID 11716489.
Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13): 11182–9. doi: 10.1074/jbc.M211230200 . PMID 12540842.
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000035720 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029254 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10518561-5] Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H (Nov 1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc Natl Acad Sci U S A. 96 (21): 11976–81. doi:10.1073/pnas.96.21.11976. PMC 18397 . PMID 10518561.

[pmid10679268-6] Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M (Mar 2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains". Biochem Biophys Res Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.

[entrez-7] 1 2 "Entrez Gene: BRDG1 BCR downstream signaling 1".

[pmid14615539-8] Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science . 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.

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STAP1

Contents

Function

Interactions

Related Research Articles

References

Further reading