STAP2

STAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EL8
Identifiers
Aliases	STAP2 , BKS, signal transducing adaptor family member 2
External IDs	OMIM: 607881; MGI: 2147039; HomoloGene: 9798; GeneCards: STAP2; OMA:STAP2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 4,324,043 bp [1] End 4,342,786 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 D Start 56,304,077 bp [2] End 56,312,584 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum skin of abdomen skin of leg rectum olfactory zone of nasal mucosa mucosa of sigmoid colon pancreatic ductal cell right lobe of liver minor salivary glands Top expressed in intestinal villus jejunum ileum duodenum parotid gland epithelium of small intestine large intestine colon crypt of lieberkuhn of small intestine submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling adaptor activity Cellular component cytoplasm cytosol plasma membrane Biological process positive regulation of tyrosine phosphorylation of STAT protein positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55620 106766 Ensembl ENSG00000178078 ENSMUSG00000038781 UniProt Q9UGK3 Q8R0L1 RefSeq (mRNA) NM_001013841 NM_017720 NM_145934 RefSeq (protein) NP_001013863 NP_060190 NP_666046 Location (UCSC) Chr 19: 4.32 – 4.34 Mb Chr 17: 56.3 – 56.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene. ^{[5] [6] [7]}

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. ^[7]

Interactions

STAP2 has been shown to interact with PTK6. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000178078 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038781 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mitchell PJ, Sara EA, Crompton MR (Oct 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID   10980601. S2CID   10682133.
6. Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L (Jul 2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID   11441184. S2CID   826987.
7. "Entrez Gene: STAP2 signal-transducing adaptor protein-2".

Further reading

• Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and characterization of a human type II receptor for bone morphogenetic proteins". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7632–6. Bibcode:1995PNAS...92.7632R. doi: 10.1073/pnas.92.17.7632 . PMC   41199 . PMID   7644468.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13): 11182–9. doi: 10.1074/jbc.M211230200 . PMID   12540842.
• Yamamoto T, Yumioka T, Sekine Y, et al. (2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells". Biochem. Biophys. Res. Commun. 306 (3): 767–73. doi:10.1016/S0006-291X(03)01042-8. PMID   12810085.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sekine Y, Yamamoto T, Yumioka T, et al. (2005). "Physical and functional interactions between STAP-2/BKS and STAT5". J. Biol. Chem. 280 (9): 8188–96. doi: 10.1074/jbc.M411692200 . hdl: 2115/28113 . PMID   15611091.
• Sekine Y, Tsuji S, Ikeda O, et al. (2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase". J. Immunol. 179 (4): 2397–407. doi: 10.4049/jimmunol.179.4.2397 . PMID   17675501.