STAU2

STAU2
Identifiers
Aliases	STAU2 , 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDs	OMIM: 605920; MGI: 1352508; HomoloGene: 8666; GeneCards: STAU2; OMA:STAU2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q21.11 Start 73,420,369 bp [1] End 73,747,708 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A3 Start 16,298,898 bp [2] End 16,590,336 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex muscle of thigh gastrocnemius muscle Brodmann area 9 right frontal lobe ventricular zone cingulate gyrus anterior cingulate cortex epithelium of colon Top expressed in Rostral migratory stream superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex medial vestibular nucleus piriform cortex deep cerebellar nuclei barrel cortex Region I of hippocampus proper facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function double-stranded RNA binding protein binding RNA binding Cellular component cytoplasm microtubule nucleolus endoplasmic reticulum membrane nucleus Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27067 29819 Ensembl ENSG00000040341 ENSMUSG00000025920 UniProt Q9NUL3 Q8CJ67 RefSeq (mRNA) NM_014393 NM_001164380 NM_001164381 NM_001164382 NM_001164383 NM_001164384 NM_001164385 NM_001111272 NM_025303 NM_001347044 NM_001347045 RefSeq (protein) NP_001157852 NP_001157853 NP_001157854 NP_001157855 NP_001157856 NP_001157857 NP_055208 NP_001104742 NP_001333973 NP_001333974 NP_079579 Location (UCSC) Chr 8: 73.42 – 73.75 Mb Chr 1: 16.3 – 16.59 Mb PubMed search [3] [4]
Wikidata
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Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene. ^{[5] [6]}

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. ^[6] Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis. ^[7] Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev ^[8] and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000040341 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025920 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID   10585778.
6. "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".
7. Cockburn, Diane M.; Charish, Jason; Tassew, Nardos G.; Eubanks, James; Bremner, Rod; Macchi, Paolo; Monnier, Philippe P. (November 2012). "The double-stranded RNA-binding protein Staufen 2 regulates eye size" . Molecular and Cellular Neuroscience. 51 (3–4): 101–111. doi:10.1016/j.mcn.2012.08.008. PMID   22940085. S2CID   5193038.
8. Banerjee, Atoshi; Benjamin, Ronald; Balakrishnan, Kannan; Ghosh, Payel; Banerjee, Sharmistha (2014-02-13). "Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev". Retrovirology. 11: 18. doi: 10.1186/1742-4690-11-18 . ISSN   1742-4690. PMC   4016256 . PMID   24520823.
9. Balakrishnan, Kannan; Jaguva Vasudevan, Ananda; Mohareer, Krishnaveni; Luedde, Tom; Münk, Carsten; Banerjee, Sharmistha (2021-12-08). "Encapsidation of Staufen-2 Enhances Infectivity of HIV-1". Viruses. 13 (12): 2459. doi: 10.3390/v13122459 . ISSN   1999-4915. PMC   8703407 . PMID   34960728.

Further reading

• Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi: 10.1016/S0896-6273(00)80868-5 . PMID   10707969. S2CID   2565210.
• Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC   2212254 . PMID   18094122.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC   371130 . PMID   15024055.
• Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. doi:10.1242/jcs.115.16.3285. PMID   12140260.