SV2B

SV2B
Identifiers
Aliases	SV2B , HsT19680, synaptic vesicle glycoprotein 2B
External IDs	OMIM: 185861; MGI: 1927338; HomoloGene: 32236; GeneCards: SV2B; OMA:SV2B - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.1 Start 91,099,950 bp [1] End 91,302,565 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D1 Start 74,764,642 bp [2] End 74,959,010 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 10 Brodmann area 23 frontal pole Brodmann area 46 orbitofrontal cortex paraflocculus of cerebellum superior frontal gyrus pons postcentral gyrus Top expressed in subiculum piriform cortex prefrontal cortex primary motor cortex dentate gyrus of hippocampal formation granule cell temporal lobe amygdala cingulate gyrus hippocampus proper superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane transporter activity transporter activity Cellular component cell junction plasma membrane synapse acrosomal vesicle membrane cytoplasmic vesicle synaptic vesicle integral component of membrane synaptic vesicle membrane neuron projection Biological process neurotransmitter transport transmembrane transport chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9899 64176 Ensembl ENSG00000185518 ENSMUSG00000053025 UniProt Q7L1I2 Q8BG39 RefSeq (mRNA) NM_001167580 NM_014848 NM_001323031 NM_001323032 NM_001323033 NM_001323034 NM_001323036 NM_001323037 NM_001323038 NM_001323039 NM_001323040 NM_001109753 NM_153579 NM_001360571 NM_001360572 NM_001360573 NM_001360574 NM_001360575 RefSeq (protein) NP_001161052 NP_001309960 NP_001309961 NP_001309962 NP_001309963 NP_001309965 NP_001309966 NP_001309967 NP_001309968 NP_001309969 NP_055663 NP_001103223 NP_705807 NP_001347500 NP_001347501 NP_001347502 NP_001347503 NP_001347504 Location (UCSC) Chr 15: 91.1 – 91.3 Mb Chr 7: 74.76 – 74.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptic vesicle glycoprotein 2B is a protein that in humans is encoded by the SV2B gene. ^{[5] [6] [7]}

See also

• SV2A

References

1. GRCh38: Ensembl release 89: ENSG00000185518 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053025 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
6. Bajjalieh SM, Peterson K, Linial M, Scheller RH (Apr 1993). "Brain contains two forms of synaptic vesicle protein 2". Proc Natl Acad Sci U S A. 90 (6): 2150–4. Bibcode:1993PNAS...90.2150B. doi: 10.1073/pnas.90.6.2150 . PMC   46043 . PMID   7681585.
7. "Entrez Gene: SV2B synaptic vesicle glycoprotein 2B".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lazzell DR, Belizaire R, Thakur P, et al. (2005). "SV2B regulates synaptotagmin 1 by direct interaction". J. Biol. Chem. 279 (50): 52124–31. doi: 10.1074/jbc.M407502200 . PMID   15466855.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Janz R, Goda Y, Geppert M, et al. (2000). "SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release". Neuron. 24 (4): 1003–16. doi: 10.1016/S0896-6273(00)81046-6 . PMID   10624962.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.