SV2A

SV2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4V11
Identifiers
Aliases	SV2A , SV2, synaptic vesicle glycoprotein 2A
External IDs	OMIM: 185860; MGI: 1927139; HomoloGene: 32237; GeneCards: SV2A; OMA:SV2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.2 Start 149,903,318 bp [1] End 149,917,844 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 96,088,467 bp [2] End 96,102,837 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 lateral nuclear group of thalamus paraflocculus of cerebellum Pars compacta frontal pole superior frontal gyrus middle temporal gyrus postcentral gyrus primary visual cortex pars reticulata Top expressed in lateral geniculate nucleus lateral hypothalamus mammillary body ventral tegmental area pontine nuclei primary visual cortex superior colliculus cerebellar cortex dorsal tegmental nucleus ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter activity transporter activity protein kinase binding signaling receptor activity Cellular component membrane synaptic vesicle cell-cell junction neuromuscular junction plasma membrane synapse presynaptic active zone cell junction endoplasmic reticulum cytoplasmic vesicle integral component of membrane integral component of synaptic vesicle membrane synaptic vesicle membrane neuron projection dendrite neuronal cell body glutamatergic synapse GABA-ergic synapse Biological process cellular calcium ion homeostasis transmembrane transport neurotransmitter transport regulation of gamma-aminobutyric acid secretion chemical synaptic transmission signal transduction synaptic vesicle priming Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9900 64051 Ensembl ENSG00000159164 ENSMUSG00000038486 UniProt Q7L0J3 Q9JIS5 RefSeq (mRNA) NM_014849 NM_001278719 NM_001328674 NM_001328675 NM_022030 RefSeq (protein) NP_001265648 NP_001315603 NP_001315604 NP_055664 NP_071313 Location (UCSC) Chr 1: 149.9 – 149.92 Mb Chr 3: 96.09 – 96.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene. ^{[5] [6] [7]} It is present in every synapse of the human nervous system, irrespective of neurotransmitter type. ^[8] The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam. ^[9]

See also

• SV2B

References

1. GRCh38: Ensembl release 89: ENSG00000159164 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038486 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2150–4. Bibcode:1993PNAS...90.2150B. doi: 10.1073/pnas.90.6.2150 . PMC   46043 . PMID   7681585.
6. Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 15268–73. Bibcode:1999PNAS...9615268C. doi: 10.1073/pnas.96.26.15268 . PMC   24809 . PMID   10611374.
7. "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A".
8. Rossi, Rachele; Arjmand, Shokouh; Bærentzen, Simone Larsen; Gjedde, Albert; Landau, Anne M. (2022-04-28). "Synaptic Vesicle Glycoprotein 2A: Features and Functions". Frontiers in Neuroscience. 16: 864514. doi: 10.3389/fnins.2022.864514 . ISSN   1662-4548. PMC   9096842 . PMID   35573314.
9. Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment. 5: 467–76. doi: 10.2147/ndt.s4844 . PMC   2747386 . PMID   19777068.

Further reading

• Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (Aug 1992). "SV2, a brain synaptic vesicle protein homologous to bacterial transporters". Science. 257 (5074): 1271–3. Bibcode:1992Sci...257.1271B. doi:10.1126/science.1519064. PMID   1519064.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
• Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS (Jan 2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry. 275 (1): 451–60. doi: 10.1074/jbc.275.1.451 . PMID   10617638.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (Jun 2004). "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam". Proceedings of the National Academy of Sciences of the United States of America. 101 (26): 9861–6. Bibcode:2004PNAS..101.9861L. doi: 10.1073/pnas.0308208101 . PMC   470764 . PMID   15210974.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. doi:10.1021/pr0498436. PMID   15822905.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• Overview of all the structural information available in the PDB for UniProt : Q7L0J3 (Synaptic vesicle glycoprotein 2A) at the PDBe-KB .