Sal Hepatica

Last updated
Sal Hepatica (1909) Sal Hepatica by Bristol Myers Co (1909).jpg
Sal Hepatica (1909)

Sal Hepatica is the name of a mineral salt laxative that was produced and marketed by Bristol-Myers from its inception in 1887, becoming its first nationally recognized product in 1903, until 1958. When dissolved in water, it was said to reproduce the taste and effect of the natural mineral waters of Bohemia. [1]

Contents

Composition and mechanism of action

The product was composed of Glauber's salt (sodium sulfate), baking soda (sodium bicarbonate), tartaric acid, common salt (sodium chloride), sodium phosphate and traces of lithium carbonate and water. [2] It was marketed as a saline laxative and alkalinizing agent. [3] [2] In the latter role it was recommended for dissolving uric acid in gout and "rheumatism", and for various other stomach, liver, and kidney disorders. [2]

See also

Related Research Articles

In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively charged sodium ions and negatively charged chloride ions.

Alum Family of double sulfate salts of aluminium

An alum is a type of chemical compound, usually a hydrated double sulfate salt of aluminium with the general formula XAl(SO
4
)
2
·12 H
2
O
, where X is a monovalent cation such as potassium or ammonium. By itself, "alum" often refers to potassium alum, with the formula KAl(SO
4
)
2
·12 H
2
O
. Other alums are named after the monovalent ion, such as sodium alum and ammonium alum.

Laxative Agents that relax and loosen the bowels and stools

Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation.

Magnesium sulfate Chemical compound with formula MgSO4

Magnesium sulfate or magnesium sulphate (in English-speaking countries other than the US) is a chemical compound, a salt with the formula MgSO4, consisting of magnesium cations Mg2+ (20.19% by mass) and sulfate anions SO2−4. It is a white crystalline solid, soluble in water but not in ethanol.

Potassium sodium tartrate Chemical compound

Potassium sodium tartrate tetrahydrate, also known as Rochelle salt, is a double salt of tartaric acid first prepared by an apothecary, Pierre Seignette, of La Rochelle, France. Potassium sodium tartrate and monopotassium phosphate were the first materials discovered to exhibit piezoelectricity. This property led to its extensive use in "crystal" gramophone (phono) pick-ups, microphones and earpieces during the post-World War II consumer electronics boom of the mid-20th century. Such transducers had an exceptionally high output with typical pick-up cartridge outputs as much as 2 volts or more. Rochelle salt is deliquescent so any transducers based on the material deteriorated if stored in damp conditions.

Magnesium chloride Inorganic salt: MgCl2 and its hydrates

Magnesium chloride is the name for the chemical compound with the formula MgCl2. In addition to the anhydrous form, MgCl2 comes in its various hydrates MgCl2·nH2O. These salts are typical ionic halides, being highly soluble in water. The magnesium chloride can be extracted from brine or sea water. In North America, magnesium chloride is produced primarily from Great Salt Lake brine. It is extracted in a similar process from the Dead Sea in the Jordan Valley. Magnesium chloride, as the mineral bischofite, is also extracted out of ancient seabeds, for example, the Zechstein seabed in northwest Europe. Some magnesium chloride is made from evaporation of seawater. Anhydrous magnesium chloride is the principal precursor to magnesium metal, which is produced on a large scale. Hydrated magnesium chloride is the form most readily available.

Sodium sulfate Chemical compound with formula Na2SO4

Sodium sulfate (also known as sodium sulphate or sulfate of soda) is the inorganic compound with formula Na2SO4 as well as several related hydrates. All forms are white solids that are highly soluble in water. With an annual production of 6 million tonnes, the decahydrate is a major commodity chemical product. It is mainly used as a filler in the manufacture of powdered home laundry detergents and in the Kraft process of paper pulping for making highly alkaline sulfides.

Potassium sulfate Chemical compound

Potassium sulfate (US) or potassium sulphate (UK), also called sulphate of potash (SOP), arcanite, or archaically potash of sulfur, is the inorganic compound with formula K2SO4, a white water-soluble solid. It is commonly used in fertilizers, providing both potassium and sulfur.

Sodium bisulfate Chemical compound

Sodium bisulfate, also known as sodium hydrogen sulfate, is the sodium salt of the bisulfate anion, with the molecular formula NaHSO4. Sodium bisulfate is an acid salt formed by partial neutralization of sulfuric acid by an equivalent of sodium base, typically in the form of either sodium hydroxide (lye) or sodium chloride (table salt). It is a dry granular product that can be safely shipped and stored. The anhydrous form is hygroscopic. Solutions of sodium bisulfate are acidic, with a 1M solution having a pH of around 1.

William McLaren Bristol was one of the two co-founders of Bristol-Myers, now part of Bristol-Myers Squibb. Myers and Bristol founded the company that would evolve into an international pharmaceutical giant in Bristol's birthplace of Clinton, New York in 1887. Bristol graduated from Hamilton College in 1887.

John Ripley Myers

John Ripley Myers was a co-founder of the pharmaceutical company Bristol-Myers.

Ipana was a toothpaste product manufactured by Bristol-Myers Company. The wintergreen flavored toothpaste reached its peak market penetration during the 1950s in North America. Marketing of Ipana used a Disney-created mascot named Bucky Beaver in the 1950s.

Beryllium hydroxide Chemical compound

Beryllium hydroxide, Be(OH)2, is an amphoteric hydroxide, dissolving in both acids and alkalis. Industrially, it is produced as a by-product in the extraction of beryllium metal from the ores beryl and bertrandite. The natural pure beryllium hydroxide is rare (in form of the mineral behoite, orthorhombic) or very rare (clinobehoite, monoclinic). When alkali is added to beryllium salt solutions the α-form (a gel) is formed. If this left to stand or boiled, the rhombic β-form precipitates. This has the same structure as zinc hydroxide, Zn(OH)2, with tetrahedral beryllium centers.

Sulfur water

Sulfur water is a condition where water is exposed to hydrogen sulfide gas, giving a distinct "rotten egg" smell. This condition has different purposes in culture varying to health and implications to plumbing.

Sani-Flush was an American brand of crystal toilet bowl cleaner formerly produced by Reckitt Benckiser. Its main ingredient was sodium bisulfate; it also contained sodium carbonate as well as sodium lauryl sulfate, talc, sodium chloride, fragrance and dye.

Manganese(II) sulfate Chemical compound

Manganese(II) sulfate usually refers to the inorganic compound with the formula MnSO4·H2O. This pale pink deliquescent solid is a commercially significant manganese(II) salt. Approximately 260,000 tonnes of manganese(II) sulfate were produced worldwide in 2005. It is the precursor to manganese metal and many other chemical compounds. Manganese-deficient soil is remediated with this salt.

Chromium(III) sulfate Chemical compound

Chromium(III) sulfate usually refers to the inorganic compounds with the formula Cr2(SO4)3.x(H2O), where x can range from 0 to 18. Additionally, ill-defined but commercially important "basic chromium sulfates" are known. These salts are usually either violet or green solids that are soluble in water. It is commonly used in tanning leather.

Seidlitz powders Laxative and digestive

Seidlitz powders is the generic name under which a commonly known laxative and digestion regulator was marketed and sold by numerous manufacturers under names such as "Rexall Seidlitz Powders", particularly in the late 19th and early 20th centuries.

References

  1. Blake, Hannah. "A history of... Bristol-Meyers Squibb". pharmaphorum. pharmaphorum media limited.
  2. 1 2 3 "Science and Sal Hepatica". JAMA. 114 (12): 1082–1083. 1940. doi:10.1001/jama.1940.02810120054015.
  3. "They all took a laxative. But that did only half the job". Bristol-Myers (advertisement). 1935.