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Chlamydia pecorum, also known as Chlamydophila pecorum is a species of Chlamydiaceae that originated from ruminants, such as cattle, sheep and goats. It has also infected koalas and swine. C. pecorum strains are serologically and pathogenically diverse.
Gammaproteobacteria is a class of bacteria in the phylum Pseudomonadota. It contains about 250 genera, which makes it the most genera-rich taxon of the Prokaryotes. Several medically, ecologically, and scientifically important groups of bacteria belong to this class. It is composed by all Gram-negative microbes and is the most phylogenetically and physiologically diverse class of Proteobacteria.
Alteromonas is a genus of Pseudomonadota found in sea water, either in the open ocean or in the coast. It is Gram-negative. Its cells are curved rods with a single polar flagellum.
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marine natural product is produced by the obligate marine bacteria Salinispora tropica and Salinispora arenicola, which are found in ocean sediment. Salinosporamide A belongs to a family of compounds, known collectively as salinosporamides, which possess a densely functionalized γ-lactam-β-lactone bicyclic core.
Nereus Pharmaceuticals was a pharmaceutical company focused on the development of natural products from marine microbial and other natural sources into small molecule human therapeutics. The major disease area addressed by Nereus is cancer. Nereus was purchased by Triphase Research and Development in 2012.
Sporolides A and B are polycyclic macrolides extracted from the obligate marine bacterium Salinispora tropica, which is found in ocean sediment. They are composed of a chlorinated cyclopenta[a]indene ring and a cyclohexenone moiety. They were the second group of compounds isolated from Salinispora, and were said to indicate the potential of marine actinomycetes as a source of novel secondary metabolites. The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.
Brachyspira aalborgi is a species of bacteria, one of the causative agents of intestinal spirochetosis. Its cells are anaerobic, sigmoidal with tapered ends, 2 to 6 µm long. Four flagella are inserted at each end of the cells. The maximal cell width is about 0.2 µm. The type strain is 513A.
The salinosporamides are a group of closely related chemical compounds isolated from marine bacteria in the genus Salinispora. They possess a densely functionalized γ-lactam-β-lactone bicyclic core.
Salinispora tropica is an obligate marine actinomycetes bacterium species. It produces salinosporamide A and salinosporamide B, potential anti-cancer agents, as well as the polycyclic macrolides sporolide A and B. The type strain is CNB-440T.
Leuconostoc carnosum is a lactic acid bacterium; its type strain is NCFB 2776. Its genome has been sequenced. Its name derives from the fact that it was first isolated from chill-stored meats. Its significance is that it thrives in anaerobic environments with a temperature around 2 °C, thus has been known to spoil vacuum-packed meat, yet it is not pathogenic and certain strains of L. carnosum are known to produce bactericides known to inhibit or kill Listeria monocytogenes.
Methanococcoides methylutens is a methylotrophic marine methanogen, the type species of its genus. It utilises trimethylamine, diethylamine, monomethylamine, and methanol as substrates for growth and methanogenesis. Cells are non-motile, non-spore-forming, irregular cocci 1 μm in diameter which stain Gram-negative and occur singly or in pairs. TMA-10 is the type strain.
Salinispora is a genus of obligately aerobic, gram-positive, non-acid-fast bacteria belonging to the family of Micromonosporaceae. They are heterotrophic, non-motile, and obligately grow under high osmotic/ionic-strength conditions. They are the first identified genus of gram-positive bacteria which has a high osmotic/ionic-strength requirement for survival. They are widely abundant in tropical marine sediments and were first identified in 2002. This genus of bacteria has potential biotechnological significance due to their production of novel secondary metabolites which can be used pharmaceutically.
Microlunatus lucidus is a Gram-positive, non-motile, aerobic actinomycete. The type strain is FA2T.
Opitutus terrae is an obligately anaerobic bacterium first isolated from rice paddy soil, hence its epithet. It is coccus-shaped and is motile by means of a flagellum. Its type strain is PB90-1T. Its genome has been sequenced.
Methylophaga thalassica is an obligately methylotrophic, Gram-negative, strictly aerobic, motile, rod-shaped bacteria. Its type strain is ATCC 33146.
Cryobacterium psychrophilum is the type species of the bacterial genus Cryobacterium. It is an obligately psychrophilic, Gram-positive irregular rod-shaped actinomycete, with type strain JCM 1463.
Micromonospora citrea is an endophytic actinomycete, with type strain DSM 43903T. It produces citreamicins, several types of antibacterial antibiotics.
Salinispora pacifica is an obligate marine actinomycetes bacterium species in the genus Salinispora.
Corynebacterium alimapuense is a species of bacteria in the genus Corynebacterium that was described as a novel species in 2019. It is a Gram positive, non-motile, aerobic bacterium that does not form spores. Its type strain was isolated from marine sediment from Valparaíso Bay, Chile. The draft genome sequence of the type strain is deposited in DNA Data Bank of Japan, European Nucleotide Archive and GenBank under the accession number PTJO00000000.
Enterocin and its derivatives are bacteriocins synthesized by the lactic acid bacteria, Enterococcus. This class of polyketide antibiotics are effective against foodborne pathogens including L. monocytogenes, Listeria, and Bacillus. Due to its proteolytic degradability in the gastrointestinal tract, enterocin is used for controlling foodborne pathogens via human consumption.
References
- ↑ Fenical, W.; Jensen, P.R.; Palladino, M.A.; Lam, K.S.; Lloyd, G.K.; Potts, B.C. (2009). "Discovery and development of the anticancer agent salinosporamide A (NPI-0052)". Bioorganic & Medicinal Chemistry. 17 (6): 2175–2180. doi:10.1016/j.bmc.2008.10.075. PMC 2814440 . PMID 19022674.
- ↑ Maldonado, L. A. (2005). "Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae". International Journal of Systematic and Evolutionary Microbiology. 55 (5): 1759–1766. doi: 10.1099/ijs.0.63625-0 . ISSN 1466-5026. PMID 16166663.
