Macedonia competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016.
Sierra Leone sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the nation's third time competing at the Summer Paralympic Games after it made its debut twenty years prior at the 1996 Summer Paralympics. The delegation consisted of a single athlete, table tennis player George Wyndham, who lost both of his preliminary round matches to Zhang Yan of China and Thailand's Wanchai Chaiwut in the men's singles class 4 tournament and advanced no further in the competition.
Madagascar sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the island country's fourth appearance at a Summer Paralympic Games since it made its debut sixteen years prior at the 2000 Summer Paralympics. Sprinter Revelinot Raherinandrasana was the sole athlete to represent the nation in Rio de Janeiro. In his event, the men's 1500 metres T45–T46, he finished tenth and last out of all the finishing athletes with a time of 4 minutes and 38.60 seconds.
The Gambia sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the nation's second appearance at the Paralympics, following their first participation in the 2012 London Paralympics. The Gambia sent one athlete, Demba Jarju, who failed to advance from his heat in the men's 100 meters T54 event.
Gabon sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the nation's third appearance at a Summer Paralympic Games, following their two previous participations at the 2008 Summer Paralympics and the 2012 Summer Paralympics. Gabon sent a sole athlete to represent them at Rio de Janeiro, wheelchair racer Edmond Ngombi. He did not advance from his heat in the men's 100 metres T54 event as he came sixth out of seven competitors and attributed the result to a handlebar problem.
Ethiopia competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016.
The Republic of the Congo competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016. The country made its debut appearance in the Paralympics at Rio, though they had participated in eleven Summer Olympics prior to the opening of the 2016 Paralympics. They sent a single competitor, track and field athlete Bardy Bouesso. Bouesso was the flagbearer at the opening ceremony.
Burkina Faso sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 to 18 September 2016. This was the country's sixth time competing at a Summer Paralympic Games after making its debut at the 1992 Summer Paralympics. Burkina Faso was represented by one athlete, Jacques Ouedraogo. He competed in one event, the men's 100 metres T54 competition, where he was eliminated in the heat stages because he was last in his heat and only the top two participants in a heat progressed to the semi-finals.
The United States Virgin Islands (USVI) sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the Virgin Islands' second time competing at a Summer Paralympic Games. They were represented by one athlete, Ivan Espinosa, who contested one event, the men's 1500 meters T37. In that event, he came in 8th place.
Trinidad and Tobago competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016.
Guatemala sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the nation's seventh time competing in the Summer Paralympic Games since it made its debut forty years prior in Toronto, Canada. Middle-distance runner Óscar Raxón Siquiej was the only athlete that Guatemala sent to Rio de Janeiro after he was awarded a wild card spot by the International Paralympic Committee. He was third and last in his heat in the men's 1500 metres T11 and failed to advance to the final since only the top six were allowed in that stage of the competition.
Haiti sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil from 7 to 18 September 2016. The country's participation in Rio marked its third appearance at the quadrennial event and its delegation consisted of one shot put thrower Jean Indris Santerre, who qualified for the games by being issued a wild card from the International Paralympic Committee after being unable to qualify on merit. He was chosen as the flag bearer for the opening ceremony. Santerre did not start the final of the men's F57 shot put competition held at the Maracanã Stadium on 17 September for unknown reasons.
Afghanistan sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the nation's fifth time taking part in a Summer Paralympic Games. The Afghan delegation consisted of a single athlete, Mohammad Durani, who competed in the javelin throw. Originally he finished 16th in his event, but he was retroactively disqualified for a doping violation.
Tajikistan sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7–18 September 2016. This was the fourth consecutive appearance of the country at the Paralympic Games after it made its debut twelve years prior at the 2004 Summer Paralympics. Tajikistan was represented by a single athlete in Rio de Janeiro: sprinter Romikhudo Dodikhudoev. He finished 14th overall in both of the men's 400 metres T47 and the men's 100 metres T47 and these performances meant he did not qualify for the final of both competitions.
Iceland competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016. Jón Margeir Sverrisson earned the top placement of the team with a fourth place in men's 200 m freestyle S14.
Suriname sent a delegation to compete at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, held from 7 to 18 September 2016. This was its fourth appearance at a Summer Paralympic Games since it debuted at the 2004 Summer Paralympics. Suriname was represented by one athlete, sprinter and long jumper Biondi Misasi, who was making his third appearance in the Paralympics. He took part in two athletics event and his best performance at these Paralympics was seventh overall in the men's 100 metres T12 event. Misasi did not progress to the final since only the top four in all heats advanced to that stage.
Cambodia competed at the 2020 Summer Paralympics in Tokyo, Japan.
Dominican Republic competed at the 2020 Summer Paralympics in Tokyo, Japan, from 24 August to 5 September 2021.
Moldova sent a delegation to participate at the 2020 Summer Paralympics in Tokyo, Japan, from 24 August to 5 September 2021. This was the Eastern European's country Seventh appearance in the Summer Paralympic Games since their debut twenty four years prior at the 1996 Summer Paralympics. Moldova sent six athletes to these Games, shot put thrower Oxana Spataur and Vladimir Butucea, powerlifter Larisa Marinenkova and Denis Raiul, Judo Player Oleg Creţul and Ion Basoc.
Togo sent a delegation to the 2020 Summer Paralympics held in Tokyo, Japan from 24 August to 5 September 2021. This marks the nation's second appearance at a Paralympic Games.
