TAC4

TAC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MOC
Identifiers
Aliases	TAC4 , EK, HK-1, HK1, PPT-C, tachykinin 4 (hemokinin), tachykinin 4, tachykinin precursor 4
External IDs	OMIM: 607833; MGI: 1931130; HomoloGene: 89219; GeneCards: TAC4; OMA:TAC4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.33 Start 49,838,300 bp [1] End 49,848,069 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 D Start 95,152,355 bp [2] End 95,160,091 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii buccal mucosa cell myocardium granulocyte vena cava cerebellar vermis anterior pituitary right lobe of thyroid gland blood left lobe of thyroid gland Top expressed in lip pineal gland olfactory epithelium tibiofemoral joint right ventricle skin of abdomen lumbar spinal ganglion aortic valve granulocyte medial ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding substance P receptor binding substance K receptor binding receptor ligand activity Cellular component extracellular region extracellular space Biological process regulation of blood pressure inflammatory response cell-cell signaling negative regulation of systemic arterial blood pressure tachykinin receptor signaling pathway regulation of signaling receptor activity detection of temperature stimulus involved in sensory perception of pain regulation of sensory perception of pain positive regulation of flagellated sperm motility negative regulation of sensory perception of pain positive regulation of sensory perception of pain positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255061 93670 Ensembl ENSG00000176358 ENSMUSG00000020872 UniProt Q86UU9 Q99N14 RefSeq (mRNA) NM_170685 NM_001077503 NM_001077504 NM_001077505 NM_001077506 NM_053093 RefSeq (protein) NP_001070971 NP_001070972 NP_001070973 NP_001070974 NP_733786 NP_444323 Location (UCSC) Chr 17: 49.84 – 49.85 Mb Chr 11: 95.15 – 95.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene. ^{[5] [6] [7]}

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1 and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000176358 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020872 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ (Mar 2001). "Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis". Nat Immunol. 1 (5): 392–7. doi:10.1038/80826. PMID   11062498. S2CID   24408728.
6. Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, Chicchi GG, Liu Q (Oct 2002). "Identification, localization and receptor characterization of novel mammalian substance P-like peptides". Gene. 296 (1–2): 205–12. doi:10.1016/S0378-1119(02)00861-2. PMID   12383518.
7. "Entrez Gene: TAC4 tachykinin 4 (hemokinin)".

Further reading

• Page NM (2007). "Characterization of the gene structures, precursor processing and pharmacology of the endokinin peptides". Vascul. Pharmacol. 45 (4): 200–8. doi:10.1016/j.vph.2005.08.028. PMID   16931167.
• Page NM (2004). "Hemokinins and endokinins". Cell. Mol. Life Sci. 61 (13): 1652–63. doi: 10.1007/s00018-004-4035-x . PMC   11138928 . PMID   15224188. S2CID   31599641.
• Cunningham S, O'Doherty C, Patterson C, et al. (2007). "The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis" (PDF). J. Neuroimmunol. 183 (1–2): 208–13. doi:10.1016/j.jneuroim.2006.11.002. PMID   17175032. S2CID   23701000.
• Page NM, Bell NJ, Gardiner SM, et al. (2003). "Characterization of the endokinins: Human tachykinins with cardiovascular activity". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6245–50. Bibcode:2003PNAS..100.6245P. doi: 10.1073/pnas.0931458100 . PMC   156357 . PMID   12716968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1". Br. J. Pharmacol. 135 (1): 266–74. doi:10.1038/sj.bjp.0704443. PMC   1573107 . PMID   11786503.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.

External links

• Overview of all the structural information available in the PDB for UniProt : Q86UU9 (Tachykinin-4) at the PDBe-KB .