TAF1C

TAF1C
Identifiers
Aliases	TAF1C , MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDs	OMIM: 604905; MGI: 109576; HomoloGene: 21163; GeneCards: TAF1C; OMA:TAF1C - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.1 Start 84,177,847 bp [1] End 84,187,070 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 120,324,610 bp [2] End 120,331,961 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary body of uterus right lobe of thyroid gland canal of the cervix left lobe of thyroid gland right uterine tube spleen gastric mucosa apex of heart Top expressed in saccule otic placode otic vesicle Ileal epithelium internal carotid artery external carotid artery corneal stroma crypt of lieberkuhn of small intestine Rostral migratory stream thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA polymerase I core promoter sequence-specific DNA binding Cellular component RNA polymerase I transcription regulator complex fibrillar center nucleoplasm nucleolus nucleus Biological process termination of RNA polymerase I transcription transcription initiation from RNA polymerase I promoter epigenetic maintenance of chromatin in transcription-competent conformation transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II regulation of transcription by RNA polymerase I RNA polymerase I preinitiation complex assembly transcription by RNA polymerase I transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9013 21341 Ensembl ENSG00000103168 ENSMUSG00000031832 UniProt Q15572 Q6PDZ2 RefSeq (mRNA) NM_001243156 NM_001243157 NM_001243158 NM_001243159 NM_001243160 NM_005679 NM_139353 NM_021441 NM_001378901 RefSeq (protein) NP_001230085 NP_001230086 NP_001230087 NP_001230088 NP_001230089 NP_005670 NP_647610 NP_067416 NP_001365830 Location (UCSC) Chr 16: 84.18 – 84.19 Mb Chr 8: 120.32 – 120.33 Mb PubMed search [3] [4]
Wikidata
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TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene. ^{[5] [6]}

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified. ^[6]

Interactions

TAF1C has been shown to interact with UBTF. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000103168 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031832 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID   7801123.
6. "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
7. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi: 10.1073/pnas.231071698 . PMC   61092 . PMID   11698641.
8. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC   86070 . PMID   10913176.

Further reading

• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID   10894955. S2CID   27014629.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC   1307603 . PMID   12393749.
• Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC   434256 . PMID   15226435.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID   15723054. S2CID   8913931.
• Friedrich JK, Panov KI, Cabart P, Russell J, Zomerdijk JC (2005). "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter". J. Biol. Chem. 280 (33): 29551–8. doi: 10.1074/jbc.M501595200 . PMC   3858828 . PMID   15970593.
• Zhang C, Comai L, Johnson DL (2005). "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC   1190253 . PMID   16055704.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.