TAF6

TAF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FUR
Identifiers
Aliases	TAF6 , MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85, TATA-box binding protein associated factor 6, ALYUS
External IDs	OMIM: 602955 MGI: 109129 HomoloGene: 7561 GeneCards: TAF6
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q22.1 Start 100,106,876 bp [1] End 100,119,841 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 138,176,879 bp [2] End 138,185,713 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium pituitary gland anterior pituitary canal of the cervix cingulate gyrus prefrontal cortex right adrenal gland right uterine tube islet of Langerhans smooth muscle tissue Top expressed in yolk sac neural tube internal carotid artery spermatid lip spermatocyte secondary oocyte triceps brachii muscle fossa seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein heterodimerization activity aryl hydrocarbon receptor binding Cellular component MLL1 complex transcription factor TFTC complex cytosol nucleus nucleoplasm SAGA complex transcription factor TFIID complex SLIK (SAGA-like) complex protein-containing complex Biological process negative regulation of cell cycle transcription initiation from RNA polymerase II promoter transcription by RNA polymerase II regulation of DNA-binding transcription factor activity transcription, DNA-templated DNA-templated transcription, initiation negative regulation of cell population proliferation regulation of transcription, DNA-templated snRNA transcription by RNA polymerase II regulation of signal transduction by p53 class mediator chromatin organization RNA polymerase II preinitiation complex assembly regulation of transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6878 21343 Ensembl ENSG00000106290 ENSMUSG00000036980 UniProt P49848 Q62311 RefSeq (mRNA) NM_001190415 NM_005641 NM_139122 NM_139123 NM_139315 NM_001364998 NM_001364999 NM_001365000 NM_001365001 NM_001365002 NM_001365003 NM_001365004 NM_009315 NM_001356600 NM_001356601 NM_001356602 RefSeq (protein) NP_001177344 NP_005632 NP_647476 NP_001351927 NP_001351928 NP_001351929 NP_001351930 NP_001351931 NP_001351932 NP_001351933 NP_033341 NP_001343529 NP_001343530 NP_001343531 Location (UCSC) Chr 7: 100.11 – 100.12 Mb Chr 5: 138.18 – 138.19 Mb PubMed search [3] [4]
Wikidata
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Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene. ^[5]

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. ^[6]

Interactions

TAF6 has been shown to interact with:

• TAF5 ^{[7] [8]} and
• TATA binding protein. ^{[9] [10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000106290 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036980 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mathé G, Schwarzenberg L, Halle-Pannenko O, Simmler MC (January 1977). "Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy". Ann N Y Acad Sci. 277: 467–84. doi:10.1111/j.1749-6632.1976.tb41721.x. PMID   826207. S2CID   33523496.
6. "Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa".
7. Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC   84812 . PMID   10523658.
8. Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG (March 1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. 272 (10): 6714–21. doi: 10.1074/jbc.272.10.6714 . PMID   9045704.
9. Pointud JC, Mengus G, Brancorsini S, Monaco L, Parvinen M, Sassone-Corsi P, Davidson I (May 2003). "The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation". J. Cell Sci. 116 (Pt 9): 1847–58. doi:10.1242/jcs.00391. PMID   12665565.
10. Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (June 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC   146709 . PMID   9153318.
11. Ruppert S, Wang EH, Tjian R (March 1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation". Nature. 362 (6416): 175–9. Bibcode:1993Natur.362..175R. doi: 10.1038/362175a0 . PMID   7680771. S2CID   4364676.

Further reading

• Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. Bibcode:1995PNAS...92.5788K. doi: 10.1073/pnas.92.13.5788 . PMC   41586 . PMID   7597030.
• Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi: 10.1073/pnas.92.17.7819 . PMC   41237 . PMID   7644498.
• Hisatake K, Ohta T, Takada R, Guermah M, Horikoshi M, Nakatani Y, Roeder RG (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195–9. Bibcode:1995PNAS...92.8195H. doi: 10.1073/pnas.92.18.8195 . PMC   41123 . PMID   7667268.
• Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat". EMBO J. 14 (2): 321–8. doi:10.1002/j.1460-2075.1995.tb07006.x. PMC   398086 . PMID   7835343.
• Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi: 10.1074/jbc.270.5.2274 . PMID   7836461.
• Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. doi:10.1128/JVI.68.11.7188-7199.1994. PMC   237158 . PMID   7933101.
• Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295–9. Bibcode:1994Natur.367..295K. doi:10.1038/367295a0. PMID   8121496. S2CID   4362048.
• Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. doi: 10.1097/00042560-199606010-00005 . PMID   8680883.
• Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. doi:10.1128/JVI.70.8.5025-5034.1996. PMC   190456 . PMID   8764009.
• Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. doi:10.1128/JVI.70.8.5503-5510.1996. PMC   190508 . PMID   8764062.
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID   8849451. S2CID   13266489.
• Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG (1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. 272 (10): 6714–21. doi: 10.1074/jbc.272.10.6714 . PMID   9045704.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi: 10.1074/jbc.272.11.6951 . PMID   9054383.
• Mahanta SK, Scholl T, Yang FC, Strominger JL (1997). "Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6324–9. Bibcode:1997PNAS...94.6324M. doi: 10.1073/pnas.94.12.6324 . PMC   21048 . PMID   9177216.
• Guermah M, Malik S, Roeder RG (1998). "Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1". Mol. Cell. Biol. 18 (6): 3234–44. doi:10.1128/mcb.18.6.3234. PMC   108905 . PMID   9584164.
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC   150203 . PMID   11406595.
• Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC   99856 . PMID   11564863.
• Bell B, Scheer E, Tora L (2001). "Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function". Mol. Cell. 8 (3): 591–600. doi: 10.1016/S1097-2765(01)00325-2 . PMID   11583621.

External links

• Overview of all the structural information available in the PDB for UniProt : P49848 (Transcription initiation factor TFIID subunit 6) at the PDBe-KB .