TAS2R14 agonist 28.1

TAS2R14 agonist 28.1

Identifiers
IUPAC name 4-methyl-N-[2-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine
CAS Number	2883007-69-8
PubChem CID	167312460
ChemSpider	129308500
ChEMBL	ChEMBL5279691
Chemical and physical data
Formula	C13H10F3N7
Molar mass	321.267 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=NC(=N1)NC2=CC=CC=C2C3=NNN=N3)C(F)(F)F
InChI InChI=1S/C13H10F3N7/c1-7-6-10(13(14,15)16)19-12(17-7)18-9-5-3-2-4-8(9)11-20-22-23-21-11/h2-6H,1H3,(H,17,18,19)(H,20,21,22,23) Key:XXKGCSWBGJTTJM-UHFFFAOYSA-N

TAS2R14 agonist 28.1 (sometimes referred to simply as 28.1) is an experimental drug that acts as a potent and selective agonist of the bitter taste receptor TAS2R14. It was developed by modification of flufenamic acid, a pharmaceutical known for a foul, bitter taste which produces bitterness via activation of TAS2R14, but is around six times more potent. TAS2R14 is also expressed in the lungs and causes bronchodilatation, so synthetic TAS2R14 agonists may be useful in the treatment of asthma and other lung diseases. ^[1]

See also

• Amarogentin
• Oligoporin D

References

1. Waterloo L, Hübner H, Fierro F, Pfeiffer T, Brox R, Löber S, et al. (March 2023). "Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14". Journal of Medicinal Chemistry. 66 (5): 3499–3521. doi:10.1021/acs.jmedchem.2c01997. PMID   36847646.