TAX1BP1

TAX1BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M7Q, 4BMJ, 4NLH, 5AAS, 4Z4M, 4Z4K
Identifiers
Aliases	TAX1BP1 , CALCOCO3, T6BP, TXBP151, Tax1 binding protein 1
External IDs	OMIM: 605326 MGI: 1289308 HomoloGene: 4395 GeneCards: TAX1BP1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,844,564 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,743,765 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; retinal pigment epithelium; ; amniotic fluid; ; cavity of mouth; ; right ventricle; ; Achilles tendon; ; caput epididymis; ; middle temporal gyrus; ; corpus epididymis;
	Top expressed in
	corneal stroma; ; olfactory epithelium; ; left colon; ; spermatid; ; seminal vesicula; ; lacrimal gland; ; sciatic nerve; ; duodenum; ; parotid gland; ; plantaris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	kinase binding ; protein binding ; metal ion binding ;
Cellular component	cytosol ; extracellular exosome ;
Biological process	regulation of tumor necrosis factor-mediated signaling pathway ; negative regulation of type I interferon production ; negative regulation of apoptotic process ; negative regulation of NF-kappaB transcription factor activity ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	8887
	52440
	ENSG00000106052
	ENSMUSG00000004535
	Q86VP1
	Q3UKC1
NM_001079864 ; NM_001206901 ; NM_001206902 ; NM_006024 ; NM_001362794 ;
	NM_001362795
	NM_025816 ; NM_001355595 ; NM_001355596
NP_001073333 ; NP_001193830 ; NP_001193831 ; NP_006015 ; NP_001349723 ;
	NP_001349724
	NP_080092 ; NP_001342524 ; NP_001342525
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Tax1-binding protein 1 is a protein that in humans is encoded by the TAX1BP1 gene.^[5]

Interactions

TAX1BP1 has been shown to interact with TNFAIP3 ^[6] and TRAF6.^[7] TAX1BP1 binds to TNFAIP3 or TRAF6 and suppresses NF-kappaB transcriptional activation.

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".
↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi: 10.1038/sj.onc.1202787 . PMID 10435631.
↑ Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi: 10.1073/pnas.170279097 . PMC 16905 . PMID 10920205.

Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi: 10.1038/sj.onc.1202787 . PMID 10435631.
Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi: 10.1073/pnas.170279097 . PMC 16905 . PMID 10920205.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (June 2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Letters. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905. S2CID 32414520.
Dodon MD, Hamaia S, Martin J, Gazzolo L (May 2002). "Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element". The Journal of Biological Chemistry. 277 (21): 18744–52. doi: 10.1074/jbc.M109087200 . PMID 11893730.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F (January 2004). "Protein profile of tax-associated complexes". The Journal of Biological Chemistry. 279 (1): 495–508. doi: 10.1074/jbc.M310069200 . PMID 14530271.
Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F (August 2007). "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion". Journal of Cell Science. 120 (Pt 15): 2574–85. doi:10.1242/jcs.007005. PMC 2621013 . PMID 17635994.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106052 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004535 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1".

[pmid10435631-6] De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi: 10.1038/sj.onc.1202787 . PMID 10435631.

[pmid10920205-7] Ling L, Goeddel DV (August 2000). "T6BP, a TRAF6-interacting protein involved in IL-1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 97 (17): 9567–72. Bibcode:2000PNAS...97.9567L. doi: 10.1073/pnas.170279097 . PMC 16905 . PMID 10920205.

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TAX1BP1

Contents

Interactions

Related Research Articles

References

Further reading