TDRD7

TDRD7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RCO
Identifiers
Aliases	TDRD7 , CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDs	OMIM: 611258; MGI: 2140279; HomoloGene: 8618; GeneCards: TDRD7; OMA:TDRD7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.33 Start 97,412,096 bp [1] End 97,496,125 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B1 Start 45,965,334 bp [2] End 46,034,761 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa retinal pigment epithelium internal globus pallidus sperm pars reticulata monocyte duodenum testicle middle frontal gyrus Top expressed in epithelium of lens spermatid neural layer of retina seminiferous tubule spermatocyte retinal pigment epithelium granulocyte mucous cell of stomach intestinal villus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA binding protein binding protein N-terminus binding RNA binding Cellular component cytoplasm chromatoid body mitochondrial matrix ribonucleoprotein granule Biological process posttranscriptional regulation of gene expression cell differentiation lens fiber cell differentiation lens morphogenesis in camera-type eye spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23424 100121 Ensembl ENSG00000196116 ENSMUSG00000035517 UniProt Q8NHU6 Q8K1H1 RefSeq (mRNA) NM_001302884 NM_014290 NM_001290475 NM_146142 NM_001355189 RefSeq (protein) NP_001289813 NP_055105 NP_001277404 NP_666254 NP_001342118 Location (UCSC) Chr 9: 97.41 – 97.5 Mb Chr 4: 45.97 – 46.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene. ^{[5] [6]}

In melanocytic cells TDRD7 gene expression may be regulated by MITF. ^[7]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown. ^[8]

Interactions

TDRD7 has been shown to interact with TACC1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000196116 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035517 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: TDRD7 tudor domain containing 7".
7. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971. S2CID   24698373.
8. Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi: 10.1177/0300060513504702 . PMID   24435515.
9. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID   14603251. S2CID   10536264.

Further reading

• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID   14603251. S2CID   10536264.
• Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC   1222467 . PMID   11903063.
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID   11527406.
• Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID   10727952.

External links

• Overview of all the structural information available in the PDB for UniProt : Q8NHU6 (Human Tudor domain-containing protein 7) at the PDBe-KB .
• Overview of all the structural information available in the PDB for UniProt : Q8K1H1 (Mouse Tudor domain-containing protein 7) at the PDBe-KB .