Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene. [4]
Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene. [4]
The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. [4]
TACC1 has been shown to interact with:
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.
The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome. Two transcript variants encoding different isoforms have been found for this gene.
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere.
Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.
ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. It was originally isolated in Drosophila melanogaster in a pathway (also known as the Scribble complex) with DLGAP5 (Discs large) and LLGL1 (Lethal giant larvae) as a tumor suppressor. In humans, SCRIB is found as a membrane protein and is involved in cell migration, cell polarity, and cell proliferation in epithelial cells. There is also strong evidence that SCRIB may play a role in cancer progression because of its strong homology to the Drosophila protein.
Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene.
Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.
U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.
Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.
Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is the homolog of the Xenopus protein XMAP215 and is also known as ch-Tog.
Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the PCTK2 gene.
In the field of molecular biology, the ETSfamily is one of the largest families of transcription factors and is unique to animals. There are 29 genes in humans, 28 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.
Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.
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