LSM7

Last updated
LSM7
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LSM7 , YNL147W, LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs OMIM: 607287 MGI: 1913344 HomoloGene: 6781 GeneCards: LSM7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016199

NM_025349
NM_001359148
NM_001359149
NM_001359150

RefSeq (protein)

NP_057283

NP_079625
NP_001346077
NP_001346078
NP_001346079

Location (UCSC) Chr 19: 2.32 – 2.33 Mb Chr 10: 80.69 – 80.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene. [5] [6] [7]

Contents

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM] [7]

Interactions

LSM7 has been shown to interact with TACC1 [8] [9] and LSM2. [10] [11]

Related Research Articles

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<span class="mw-page-title-main">LSM6</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

<span class="mw-page-title-main">LSM5</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.

<span class="mw-page-title-main">LSM4</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.

<span class="mw-page-title-main">LSM1</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm1 is a protein that in humans is encoded by the LSM1 gene.

<span class="mw-page-title-main">LSM3</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.

<span class="mw-page-title-main">TACC1</span> Protein-coding gene in the species Homo sapiens

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.

<span class="mw-page-title-main">LSM2</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

<span class="mw-page-title-main">LSM8</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.

<span class="mw-page-title-main">CKAP5</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">INTS6</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LSM10</span> Protein-coding gene in the species Homo sapiens

U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the LSM10 gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130332 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035215 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC   1171645 . PMID   10523320.
  6. Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC   1370355 . PMID   12515382.
  7. 1 2 "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  8. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID   14603251. S2CID   10536264.
  9. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi: 10.1038/sj.onc.1205658 . PMID   12165861.
  10. Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
  11. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.

Further reading