LSM7

LSM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM7 , YNL147W, LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607287; MGI: 1913344; HomoloGene: 6781; GeneCards: LSM7; OMA:LSM7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 2,321,520 bp [1] End 2,328,611 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 80,688,655 bp [2] End 80,691,043 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte ganglionic eminence pituitary gland ventricular zone spleen anterior pituitary monocyte C1 segment left ovary Top expressed in embryo yolk sac embryo blastocyst morula ventricular zone dentate gyrus of hippocampal formation granule cell neural layer of retina lip thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding U6 snRNA binding Cellular component cytosol catalytic step 2 spliceosome spliceosomal tri-snRNP complex U6 snRNP U12-type spliceosomal complex nucleoplasm Lsm1-7-Pat1 complex spliceosomal complex U2-type prespliceosome nucleus U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Lsm2-8 complex Biological process mRNA splicing, via spliceosome RNA processing mRNA processing exonucleolytic catabolism of deadenylated mRNA RNA splicing nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51690 66094 Ensembl ENSG00000130332 ENSMUSG00000035215 UniProt Q9UK45 Q9CQQ8 RefSeq (mRNA) NM_016199 NM_025349 NM_001359148 NM_001359149 NM_001359150 RefSeq (protein) NP_057283 NP_079625 NP_001346077 NP_001346078 NP_001346079 Location (UCSC) Chr 19: 2.32 – 2.33 Mb Chr 10: 80.69 – 80.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene. ^{[5] [6] [7]}

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM] ^[7]

Interactions

LSM7 has been shown to interact with TACC1 ^{[8] [9]} and LSM2. ^{[10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000130332 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035215 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC   1171645 . PMID   10523320.
6. Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC   1370355 . PMID   12515382.
7. "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
8. Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID   14603251. S2CID   10536264.
9. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi: 10.1038/sj.onc.1205658 . PMID   12165861.
10. Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
11. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.

Further reading

• Friesen WJ, Dreyfuss G (Aug 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". The Journal of Biological Chemistry. 275 (34): 26370–5. doi: 10.1074/jbc.M003299200 . PMID   10851237.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC   311163 . PMID   11591653.
• Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and Rheumatism. 46 (3): 726–34. doi: 10.1002/art.10220 . PMID   11920408.
• Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi: 10.1038/sj.onc.1205658 . PMID   12165861.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID   14603251. S2CID   10536264.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Stanĕk D, Neugebauer KM (Sep 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". The Journal of Cell Biology. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC   2172029 . PMID   15452143.