TELO2

TELO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PSI
Identifiers
Aliases	TELO2 , CLK2, TEL2, telomere maintenance 2, YHFS
External IDs	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 1,493,344 bp [1] End 1,510,457 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A3.3 Start 25,318,544 bp [2] End 25,334,941 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of liver gastric mucosa spleen canal of the cervix anterior pituitary right lobe of thyroid gland left uterine tube tibial nerve left lobe of thyroid gland Top expressed in molar inferior colliculus paraventricular nucleus of hypothalamus olfactory tubercle globus pallidus external carotid artery medial geniculate nucleus subiculum arcuate nucleus ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity Hsp90 protein binding protein binding protein kinase binding protein-containing complex binding telomeric DNA binding Cellular component cytoplasm telomere TORC1 complex TORC2 complex intracellular anatomical structure membrane nuclear periphery nucleus chromosome cytosol nuclear body ASTRA complex Biological process positive regulation of TORC1 signaling protein stabilization regulation of TOR signaling positive regulation of TORC2 signaling positive regulation of protein serine/threonine kinase activity telomere maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9894 71718 Ensembl ENSG00000100726 ENSMUSG00000024170 UniProt Q9Y4R8 Q9DC40 RefSeq (mRNA) NM_016111 NM_001351846 NM_001163661 NM_027880 RefSeq (protein) NP_057195 NP_001338775 NP_001157133 NP_082156 Location (UCSC) Chr 16: 1.49 – 1.51 Mb Chr 17: 25.32 – 25.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene. ^{[5] [6] [7] [8]}

Function

In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR and is a highly conserved regulator of PIKK stability. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
7. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi: 10.1074/jbc.M300286200 . PMID   12670948.
8. "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
9. Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi: 10.1016/j.cell.2007.10.052 . PMID   18160036. S2CID   6297247.

Further reading

• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9Y4R8 (Human Telomere length regulation protein TEL2 homolog) at the PDBe-KB .