TFDP1

TFDP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AZE
Identifiers
Aliases	TFDP1 , DP1, DRTF1, Dp-1, DILC, transcription factor Dp-1
External IDs	OMIM: 189902; MGI: 101934; HomoloGene: 38276; GeneCards: TFDP1; OMA:TFDP1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q34 Start 113,584,721 bp [1] End 113,641,473 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 13,338,751 bp [2] End 13,378,448 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone ventricular zone bone marrow stromal cell of endometrium ganglionic eminence rectum olfactory zone of nasal mucosa mucosa of esophagus buccal mucosa cell Top expressed in granulocyte epiblast ventricular zone dermis tail of embryo abdominal wall fetal liver hematopoietic progenitor cell hair follicle genital tubercle primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein domain specific binding DNA-binding transcription factor activity protein binding transcription coactivator activity transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus mitochondrion nucleoplasm cytosol cytoplasm RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway cell cycle cell population proliferation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transcription, DNA-templated regulation of transcription involved in G1/S transition of mitotic cell cycle transcription by RNA polymerase II negative regulation of G0 to G1 transition positive regulation of transcription by RNA polymerase II negative regulation of fat cell proliferation epidermis development anoikis positive regulation of transcription, DNA-templated regulation of cell cycle regulation of DNA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7027 21781 Ensembl ENSG00000198176 ENSMUSG00000038482 UniProt Q14186 Q08639 RefSeq (mRNA) NM_007111 NM_001291765 NM_001291766 NM_001291768 NM_009361 NM_001358991 RefSeq (protein) NP_009042 NP_001278694 NP_001278695 NP_001278697 NP_033387 NP_001345920 Location (UCSC) Chr 13: 113.58 – 113.64 Mb Chr 8: 13.34 – 13.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene. ^{[5] [6] [7]}

Function

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM] ^[7]

Interactions

TFDP1 has been shown to interact with:

• E2F1, ^{[8] [9] [10] [11]}
• E2F5, ^{[8] [12]} and
• P53. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000198176 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038482 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993). "A new component of the transcription factor DRTF1/E2F". Nature. 365 (6445): 468. Bibcode:1993Natur.365R.468G. doi: 10.1038/365468d0 . PMID   8413592.
6. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID   9027491.
7. "Entrez Gene: TFDP1 transcription factor Dp-1".
8. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. Bibcode:1995PNAS...92.2403S. doi: 10.1073/pnas.92.6.2403 . PMC   42492 . PMID   7892279.
9. Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID   9780002. S2CID   23588950.
10. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (May 1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC   230484 . PMID   7739537.
11. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (Oct 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi: 10.1101/gad.7.10.1850 . PMID   8405995.
12. Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC   230539 . PMID   7760804.
13. Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (Oct 1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC   231590 . PMID   8816502.

Further reading

• Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC   230484 . PMID   7739537.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC   230539 . PMID   7760804.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. Bibcode:1995PNAS...92.2403S. doi: 10.1073/pnas.92.6.2403 . PMC   42492 . PMID   7892279.
• Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes Dev. 8 (22): 2665–79. doi: 10.1101/gad.8.22.2665 . PMID   7958924.
• Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo". Genes Dev. 8 (22): 2680–90. doi: 10.1101/gad.8.22.2680 . PMID   7958925.
• Bandara LR, Lam EW, Sørensen TS, Zamanian M, Girling R, La Thangue NB (1994). "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein". EMBO J. 13 (13): 3104–14. doi:10.1002/j.1460-2075.1994.tb06609.x. PMC   395201 . PMID   8039504.
• Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E (1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. 7 (10): 1850–61. doi: 10.1101/gad.7.10.1850 . PMID   8405995.
• Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. Bibcode:1996PNAS...93.7594R. doi: 10.1073/pnas.93.15.7594 . PMC   38791 . PMID   8755520.
• Sørensen TS, Girling R, Lee CW, Gannon J, Bandara LR, La Thangue NB (1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. 16 (10): 5888–95. doi:10.1128/mcb.16.10.5888. PMC   231590 . PMID   8816502.
• Vidal M, Braun P, Chen E, Boeke JD, Harlow E (1996). "Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10321–6. Bibcode:1996PNAS...9310321V. doi: 10.1073/pnas.93.19.10321 . PMC   38382 . PMID   8816798.
• Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". J. Cell Sci. 109. ( Pt 7) (7): 1717–26. doi:10.1242/jcs.109.7.1717. PMID   8832394.
• Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. doi: 10.1101/gad.10.7.851 . PMID   8846921.
• Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. Bibcode:1998PNAS...95.2850T. doi: 10.1073/pnas.95.6.2850 . PMC   19658 . PMID   9501179.
• Cartwright P, Müller H, Wagener C, Holm K, Helin K (1998). "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription". Oncogene. 17 (5): 611–23. doi:10.1038/sj.onc.1201975. PMID   9704927. S2CID   7688110.
• Timchenko NA, Wilde M, Darlington GJ (1999). "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice". Mol. Cell. Biol. 19 (4): 2936–45. doi:10.1128/mcb.19.4.2936. PMC   84088 . PMID   10082561.
• Lam EW, Glassford J, van der Sman J, Banerji L, Pizzey AR, Shaun N, Thomas B, Klaus GG (1999). "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors". Eur. J. Immunol. 29 (10): 3380–9. doi: 10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C . PMID   10540350.
• Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID   11042687. S2CID   41370242.
• Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC   125435 . PMID   11331592.