TIAL1

TIAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4G, 2CQI, 2DH7
Identifiers
Aliases	TIAL1 , TCBP, TIAR, TIA1 cytotoxic granule-associated RNA binding protein-like 1, TIA1 cytotoxic granule associated RNA binding protein like 1
External IDs	OMIM: 603413 MGI: 107913 HomoloGene: 87796 GeneCards: TIAL1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.11 Start 119,571,802 bp [1] End 119,597,029 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 128,439,777 bp [2] End 128,461,717 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left lobe of thyroid gland canal of the cervix tibia minor salivary gland skin of abdomen lymph node right lung right lobe of thyroid gland gallbladder Top expressed in cerebellar cortex medullary collecting duct Paneth cell spermatocyte paraventricular nucleus of hypothalamus arcuate nucleus superior frontal gyrus cerebellar vermis habenula atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding RNA binding DNA binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasm cytoplasmic stress granule lysosome extracellular exosome nucleus nucleoplasm ribonucleoprotein complex Biological process regulation of transcription by RNA polymerase II germ cell development defense response stem cell division positive regulation of cell population proliferation apoptotic process fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7073 21843 Ensembl ENSG00000151923 ENSMUSG00000030846 UniProt Q01085 P70318 RefSeq (mRNA) NM_001033925 NM_003252 NM_001323964 NM_001323965 NM_001323967 NM_001323968 NM_001323969 NM_001323970 NM_022333 NM_009383 NM_001347640 NM_001347641 RefSeq (protein) NP_001029097 NP_001310893 NP_001310894 NP_001310896 NP_001310897 NP_001310898 NP_001310899 NP_003243 NP_001334569 NP_001334570 NP_033409 Location (UCSC) Chr 10: 119.57 – 119.6 Mb Chr 7: 128.44 – 128.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleolysin TIAR is a protein that in humans is encoded by the TIAL1 gene. ^{[5] [6]}

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been shown to function differently with respect to post-transcriptional silencing. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000151923 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030846 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kawakami A, Tian Q, Duan X, Streuli M, Schlossman SF, Anderson P (Oct 1992). "Identification and functional characterization of a TIA-1-related nucleolysin". Proc Natl Acad Sci U S A. 89 (18): 8681–5. Bibcode:1992PNAS...89.8681K. doi: 10.1073/pnas.89.18.8681 . PMC   49984 . PMID   1326761.
6. "Entrez Gene: TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1".

Further reading

• Taupin JL, Tian Q, Kedersha N, et al. (1995). "The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1629–33. Bibcode:1995PNAS...92.1629T. doi: 10.1073/pnas.92.5.1629 . PMC   42573 . PMID   7533298.
• Dember LM, Kim ND, Liu KQ, Anderson P (1996). "Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities". J. Biol. Chem. 271 (5): 2783–8. doi: 10.1074/jbc.271.5.2783 . PMID   8576255.
• Doi T, Minami T, Itoh M, et al. (1997). "An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene". Biochem. Biophys. Res. Commun. 235 (3): 625–30. doi:10.1006/bbrc.1997.6817. PMID   9207209.
• Jin K, Li W, Nagayama T, et al. (2000). "Expression of the RNA-binding protein TIAR is increased in neurons after ischemic cerebral injury". J. Neurosci. Res. 59 (6): 767–74. doi:10.1002/(SICI)1097-4547(20000315)59:6<767::AID-JNR9>3.0.CO;2-K. PMID   10700014. S2CID   33671199.
• Le Guiner C, Lejeune F, Galiana D, et al. (2001). "TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs". J. Biol. Chem. 276 (44): 40638–46. doi: 10.1074/jbc.M105642200 . PMID   11514562.
• Iseni F, Garcin D, Nishio M, et al. (2002). "Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis". EMBO J. 21 (19): 5141–50. doi:10.1093/emboj/cdf513. PMC   129035 . PMID   12356730.
• Li W, Li Y, Kedersha N, et al. (2002). "Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication". J. Virol. 76 (23): 11989–2000. doi:10.1128/JVI.76.23.11989-12000.2002. PMC   136884 . PMID   12414941.
• Yu Q, Cok SJ, Zeng C, Morrison AR (2003). "Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR)". J. Biol. Chem. 278 (3): 1579–84. doi: 10.1074/jbc.M203526200 . PMID   12426321.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Le Guiner C, Gesnel MC, Breathnach R (2003). "TIA-1 or TIAR is required for DT40 cell viability". J. Biol. Chem. 278 (12): 10465–76. doi: 10.1074/jbc.M212378200 . PMID   12533540.
• Cok SJ, Acton SJ, Morrison AR (2003). "The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U." J. Biol. Chem. 278 (38): 36157–62. doi: 10.1074/jbc.M302547200 . PMID   12855701.
• Zhu H, Hasman RA, Young KM, et al. (2003). "U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA". Mol. Cell. Biol. 23 (17): 5959–71. doi:10.1128/MCB.23.17.5959-5971.2003. PMC   180986 . PMID   12917321.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Shukla S, Dirksen WP, Joyce KM, et al. (2004). "TIA proteins are necessary but not sufficient for the tissue-specific splicing of the myosin phosphatase targeting subunit 1". J. Biol. Chem. 279 (14): 13668–76. doi: 10.1074/jbc.M314138200 . PMID   14736875.
• Esclatine A, Taddeo B, Roizman B (2004). "Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs". J. Virol. 78 (16): 8582–92. doi:10.1128/JVI.78.16.8582-8592.2004. PMC   479066 . PMID   15280467.
• Hua Y, Zhou J (2004). "Survival motor neuron protein facilitates assembly of stress granules". FEBS Lett. 572 (1–3): 69–74. doi: 10.1016/j.febslet.2004.07.010 . PMID   15304326. S2CID   27599172.
• Suswam EA, Nabors LB, Huang Y, et al. (2005). "IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. 113 (6): 911–9. doi: 10.1002/ijc.20675 . PMID   15514971. S2CID   33272692.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Suswam EA, Li YY, Mahtani H, King PH (2005). "Novel DNA-binding properties of the RNA-binding protein TIAR". Nucleic Acids Res. 33 (14): 4507–18. doi:10.1093/nar/gki763. PMC   1184220 . PMID   16091628.

External links

• Overview of all the structural information available in the PDB for UniProt : Q01085 (Nucleolysin TIAR) at the PDBe-KB .