TM4SF5

TM4SF5
Identifiers
Aliases	TM4SF5 , transmembrane 4 L six family member 5
External IDs	OMIM: 604657 MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,783,213 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,402,004 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right lobe of liver; ; duodenum; ; kidney tubule; ; rectum; ; kidney; ; glomerulus; ; metanephric glomerulus; ; body of stomach; ; gallbladder;
	Top expressed in
	duodenum; ; jejunum; ; crypt of lieberkuhn of small intestine; ; ileum; ; Intestinal epithelium; ; mucous cell of stomach; ; intestinal villus; ; Epithelium of stomach; ; Paneth cell; ; yolk sac;
	More reference expression data
	More reference expression data
Orthologs
	9032
	75604
	ENSG00000142484
	ENSMUSG00000018919
	O14894
	n/a
	NM_003963
	NM_029360
	NP_003954
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.^[5]^[6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.^[6]

Related Research Articles

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.

CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

CD151 molecule, also known as CD151, is a human gene.

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene. IGSF8 has also been designated as CD316.

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142484 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018919 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.
1 2 "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Lee SY, Kim YT, Lee MS, et al. (2006). "Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment". Exp. Cell Res. 312 (16): 2983–99. doi:10.1016/j.yexcr.2006.06.001. hdl: 10371/3238 . PMID 16828471.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". Am. J. Gastroenterol. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983. S2CID 31864317.
Wright MD, Ni J, Rudy GB (2000). "The L6 membrane proteins--a new four-transmembrane superfamily". Protein Sci. 9 (8): 1594–600. doi:10.1110/ps.9.8.1594. PMC 2144728 . PMID 10975581.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142484 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018919 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479038-5] Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.

[entrez-6] 1 2 "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".

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TM4SF5

Related Research Articles

References

Further reading