TMPRSS11D

Last updated
TMPRSS11D
Identifiers
Aliases TMPRSS11D , HAT, transmembrane protease, serine 11D, transmembrane serine protease 11D, ASP
External IDs OMIM: 605369 MGI: 2385221 HomoloGene: 74519 GeneCards: TMPRSS11D
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004262

NM_145561

RefSeq (protein)

NP_004253

NP_663536

Location (UCSC) Chr 4: 67.82 – 67.88 Mb Chr 5: 86.45 – 86.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transmembrane protease, serine 11D is an enzyme that in humans is encoded by the TMPRSS11D gene. [5] [6] [7]

Contents

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [7]

Related Research Articles

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<span class="mw-page-title-main">Maspin</span> Protein-coding gene in the species Homo sapiens

Maspin is a protein that in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin superfamily. SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and metastasize to other tissues. Furthermore, and consistent with an important biological function, Maspin knockout mice were reported to be non-viable, dying in early embryogenesis. However, a subsequent study using viral transduction as a method of gene transfer was not able to reproduce the original findings and found no role for maspin in tumour biology. Furthermore, the latter study demonstrated that maspin knockout mice are viable and display no obvious phenotype. These data are consistent with the observation that maspin is not expressed in early embryogenesis. The precise molecular function of maspin is thus currently unknown.

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<span class="mw-page-title-main">F2RL3</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Trypsin 1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ST14</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Kallikrein-5</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Serine protease HTRA1</span> Protein-coding gene in the species Homo sapiens

Serine protease HTRA1 is an enzyme that in humans is encoded by the HTRA1 gene. The HTRA1 protein is composed of four distinct protein domains. They are from amino-terminus to carboxyl-terminus an Insulin-like growth factor binding domain, a kazal domain, a trypsin-like peptidase domain and a PDZ domain.

<span class="mw-page-title-main">SPINT1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">LEKTI</span> Protein-coding gene in the species Homo sapiens

Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.

<span class="mw-page-title-main">KLK11</span> Protein-coding gene in the species Homo sapiens

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

<span class="mw-page-title-main">SERPINB6</span> Protein-coding gene in the species Homo sapiens

Serpin B6 is a protein that in humans is encoded by the SERPINB6 gene.

<span class="mw-page-title-main">PRSS23</span> Protein-coding gene in the species Homo sapiens

Serine protease 23 is an enzyme that in humans is encoded by the PRSS23 gene.

<span class="mw-page-title-main">TMPRSS6</span> Protein-coding gene in the species Homo sapiens

Transmembrane protease, serine 6 is an enzyme that in humans is encoded by the TMPRSS6 gene.

<span class="mw-page-title-main">GZMM</span> Protein-coding gene in the species Homo sapiens

Granzyme M is a protein that in humans is encoded by the GZMM gene.

<span class="mw-page-title-main">CELA3A</span> Protein-coding gene in the species Homo sapiens

Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.

<span class="mw-page-title-main">SERPINA9</span> Protein-coding gene in the species Homo sapiens

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1. Serpin A9 is a member of the serpin family of serine protease inhibitors.

<span class="mw-page-title-main">TPSG1</span> Protein-coding gene in the species Homo sapiens

Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene.

<span class="mw-page-title-main">PRSS22</span> Protein-coding gene in the species Homo sapiens

Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153802 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000061259 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S (Jun 1998). "Cloning and characterization of the cDNA for human airway trypsin-like protease". J Biol Chem. 273 (19): 11895–901. doi: 10.1074/jbc.273.19.11895 . PMID   9565616.
  6. Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T (Apr 1997). "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway". Am J Respir Cell Mol Biol. 16 (3): 300–8. doi:10.1165/ajrcmb.16.3.9070615. PMID   9070615.
  7. 1 2 "Entrez Gene: TMPRSS11D transmembrane protease, serine 11D". Archived from the original on 2024-04-30. Retrieved 2017-09-15.

Further reading