TPD52

TPD52
Identifiers
Aliases	TPD52 , D52, N8L, PC-1, PrLZ, hD52, tumor protein D52
External IDs	OMIM: 604068 MGI: 107749 HomoloGene: 38007 GeneCards: TPD52
Gene location (Human)
Chr.	Chromosome 8 (human)
End	80,231,232 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	9,069,783 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; secondary oocyte; ; endothelial cell; ; islet of Langerhans; ; parotid gland; ; rectum; ; duodenum; ; Brodmann area 23; ; pons; ; thymus;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; pyloric antrum; ; salivary gland; ; left colon; ; lacrimal gland; ; submandibular gland; ; epithelium of stomach; ; ileum; ; mucous cell of stomach; ; parotid gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; protein binding ; protein homodimerization activity ; protein heterodimerization activity ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; endoplasmic reticulum ;
Biological process	B cell differentiation ; anatomical structure morphogenesis ; secretion ;
	Sources:Amigo / QuickGO
Orthologs
	7163
	21985
	ENSG00000076554
	ENSMUSG00000027506
	P55327
	Q62393
NM_001025252 ; NM_001025253 ; NM_001287140 ; NM_001287142 ; NM_001287143 ;
	NM_001287144 ; NM_005079 ; NM_001387779 ; NM_001387780
NM_001025261 ; NM_001025262 ; NM_001025263 ; NM_001025264 ; NM_009412 ;
	NM_001357072 ; NM_001357073 ; NM_001357074
NP_001020423 ; NP_001020424 ; NP_001274069 ; NP_001274071 ; NP_001274072 ;
	NP_001274073 ; NP_005070
NP_001020432 ; NP_001020433 ; NP_001020434 ; NP_001020435 ; NP_033438 ;
	NP_001344001 ; NP_001344002 ; NP_001344003
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 25, 2023

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.^[5]^[6]

Interactions

TPD52 has been shown to interact with TPD52L2,^[7] TPD52L1 ^[7] and MAL2.^[8]

Related Research Articles

Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene.

Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.

Serine/threonine-protein kinase A-Raf or simply A-Raf is an enzyme that in humans is encoded by the ARAF gene. A-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.

Non-histone chromosomal protein HMG-17 is a protein that in humans is encoded by the HMGN2 gene.

Nucleoporin 88 (Nup88) is a protein that in humans is encoded by the NUP88 gene.

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.

Tumor protein D52 is a protein that in humans is encoded by the TPD52L1 gene.

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.

40S ribosomal protein S8 is a protein that in humans is encoded by the RPS8 gene.

Angio-associated, migratory cell protein, also known as AAMP, is a protein which in humans is encoded by the AAMP gene. This protein has been conserved in evolution and is so common to many mammals. and it also has a yeast homolog which is the protein YCR072c.

Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene. It encodes a protein that performs posttranslational modification of histidine-715 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation of Cyclin D in ovarian cells. DPH1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.

Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene.

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000076554 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027506 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (August 1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–903. PMID 7796418.
↑ "Entrez Gene: TPD52 tumor protein D52".
1 2 Byrne JA, Nourse CR, Basset P, Gunning P (February 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
↑ Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (August 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chen SL, Maroulakou IG, Green JE, Romano-Spica V, Modi W, Lautenberger J, Bhat NK (1996). "Isolation and characterization of a novel gene expressed in multiple cancers". Oncogene. 12 (4): 741–51. PMID 8632896.
Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
Wang R, Xu J, Saramäki O, Visakorpi T, Sutherland WM, Zhou J, Sen B, Lim SD, Mabjeesh N, Amin M, Dong JT, Petros JA, Nelson PS, Marshall FF, Zhau HE, Chung LW (2004). "PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer". Cancer Res. 64 (5): 1589–94. doi: 10.1158/0008-5472.CAN-03-3331 . PMID 14996714.
Tiacci E, Orvietani PL, Bigerna B, Pucciarini A, Corthals GL, Pettirossi V, Martelli MP, Liso A, Benedetti R, Pacini R, Bolli N, Pileri S, Pulford K, Gambacorta M, Carbone A, Pasquarello C, Scherl A, Robertson H, Sciurpi MT, Alunni-Bistocchi G, Binaglia L, Byrne JA, Falini B (2005). "Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI". Blood. 105 (7): 2812–20. doi: 10.1182/blood-2004-07-2630 . hdl: 2434/602659 . PMID 15576473.
Byrne JA, Balleine RL, Schoenberg Fejzo M, Mercieca J, Chiew YE, Livnat Y, St Heaps L, Peters GB, Byth K, Karlan BY, Slamon DJ, Harnett P, Defazio A (2005). "Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer". Int. J. Cancer. 117 (6): 1049–54. doi: 10.1002/ijc.21250 . PMID 15986428. S2CID 38845575.
Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000076554 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027506 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7796418-5] Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (August 1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–903. PMID 7796418.

[entrez-6] "Entrez Gene: TPD52 tumor protein D52".

[pmid9484778-7] 1 2 Byrne JA, Nourse CR, Basset P, Gunning P (February 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.

[pmid11549320-8] Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (August 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

TPD52

Contents

Interactions

Related Research Articles

References

Further reading