TPD52L1

TPD52L1
Identifiers
Aliases	TPD52L1 , D53, hD53, tumor protein D52-like 1, tumor protein D52 like 1, TPD52 like 1, TPD53
External IDs	OMIM: 604069 MGI: 1298386 HomoloGene: 2468 GeneCards: TPD52L1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	125,264,407 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	31,321,954 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; germinal epithelium; ; Left adrenal gland; ; putamen; ; pancreatic ductal cell; ; minor salivary gland; ; external globus pallidus; ; nucleus accumbens; ; caudate nucleus; ; triceps brachii muscle;
	Top expressed in
	seminal vesicula; ; parotid gland; ; submandibular gland; ; extraocular muscle; ; fourth ventricle; ; lateral geniculate nucleus; ; intercostal muscle; ; facial motor nucleus; ; soleus muscle; ; superior colliculus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein homodimerization activity ; identical protein binding ; protein heterodimerization activity ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ;
Biological process	positive regulation of apoptotic signaling pathway ; positive regulation of JNK cascade ; G2/M transition of mitotic cell cycle ; positive regulation of MAP kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	7164
	21987
	ENSG00000111907
	ENSMUSG00000000296
	Q16890
	O54818
NM_001003395 ; NM_001003396 ; NM_001003397 ; NM_001292026 ; NM_001300994 ;
	NM_003287 ; NM_001318903 ; NM_001318907
	NM_009413 ; NM_001359364 ; NM_001359365 ; NM_001359366
NP_001003395 ; NP_001003396 ; NP_001003397 ; NP_001278955 ; NP_001287923 ;
	NP_001305832 ; NP_001305836 ; NP_003278
	NP_033439 ; NP_001346293 ; NP_001346294 ; NP_001346295
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 24, 2022

Tumor protein D52 is a protein that in humans is encoded by the TPD52L1 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.^[7]

Interactions

TPD52L1 has been shown to interact with TPD52L2 ^[8] and TPD52.^[8]

Related Research Articles

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effecter of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in the unfolded protein response.

Securin is a protein that in humans is encoded by the PTTG1 gene.

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

Inositol-trisphosphate 3-kinase A is an enzyme that in humans is encoded by the ITPKA gene.

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.

Protein ajuba is a protein that in humans is encoded by the JUB gene.

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111907 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000296 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Byrne JA, Mattei MG, Basset P (Dec 1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–532. doi:10.1006/geno.1996.0393. PMID 8812487.
↑ Boutros R, Byrne JA (Oct 2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–165. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
1 2 "Entrez Gene: TPD52L1 tumor protein D52-like 1".
1 2 Byrne JA, Nourse CR, Basset P, Gunning P (Feb 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–881. doi: 10.1038/sj.onc.1201604 . PMID 9484778.

Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence". Cancer Res. 55 (13): 2896–2903. PMID 7796418.
Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–881. doi: 10.1038/sj.onc.1201604 . PMID 9484778.
Byrne JA, Mattei MG, Basset P, Gunning P (1998). "Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2". Cytogenet. Cell Genet. 81 (3–4): 199–201. doi:10.1159/000015029. PMID 9730602. S2CID 46742110.
Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–88. doi:10.1006/geno.2001.6610. PMID 11549320.
Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–687. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC (2004). "Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1". J. Biol. Chem. 279 (16): 16050–16056. doi: 10.1074/jbc.M305758200 . PMID 14761963.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2006). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–1363. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111907 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000296 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812487-5] Byrne JA, Mattei MG, Basset P (Dec 1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–532. doi:10.1006/geno.1996.0393. PMID 8812487.

[pmid16112108-6] Boutros R, Byrne JA (Oct 2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–165. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.

[entrez-7] 1 2 "Entrez Gene: TPD52L1 tumor protein D52-like 1".

[pmid9484778-8] 1 2 Byrne JA, Nourse CR, Basset P, Gunning P (Feb 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–881. doi: 10.1038/sj.onc.1201604 . PMID 9484778.

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TPD52L1

Contents

Function

Interactions

Related Research Articles

References

Further reading