TRAM2

TRAM2
Identifiers
Aliases	TRAM2 , translocation associated membrane protein 2
External IDs	OMIM: 608485; MGI: 1924817; HomoloGene: 8183; GeneCards: TRAM2; OMA:TRAM2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.2 Start 52,497,408 bp [1] End 52,577,060 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A4 Start 21,066,523 bp [2] End 21,149,453 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte stromal cell of endometrium placenta cartilage tissue tibia synovial membrane synovial joint mucosa of ileum visceral pleura Top expressed in ascending aorta aortic valve cumulus cell calvaria body of femur mesenteric lymph nodes umbilical cord endothelial cell of lymphatic vessel tail of embryo ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane rough endoplasmic reticulum Biological process protein transport collagen biosynthetic process protein insertion into ER membrane SRP-dependent cotranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9697 170829 Ensembl ENSG00000065308 ENSMUSG00000041779 UniProt Q15035 Q924Z5 RefSeq (mRNA) NM_012288 NM_177409 RefSeq (protein) NP_036420 NP_803128 Location (UCSC) Chr 6: 52.5 – 52.58 Mb Chr 1: 21.07 – 21.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene. ^{[5] [6] [7]}

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000065308 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041779 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
6. Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID   10594243. S2CID   11705244.
7. "Entrez Gene: TRAM2 translocation associated membrane protein 2".

Further reading

• Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics. 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID   7698749.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Hsu LC, Liu S, Abedinpour F, et al. (2003). "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription". Mol. Cell. Biol. 23 (23): 8773–85. doi:10.1128/MCB.23.23.8773-8785.2003. PMC   262660 . PMID   14612417.
• Stefanovic B, Stefanovic L, Schnabl B, et al. (2004). "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis". Mol. Cell. Biol. 24 (4): 1758–68. doi:10.1128/MCB.24.4.1758-1768.2004. PMC   344171 . PMID   14749390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.