TRIP10

TRIP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CT4, 2EFK, 2KE4
Identifiers
Aliases	TRIP10 , CIP4, HSTP, STOT, STP, TRIP-10, thyroid hormone receptor interactor 10
External IDs	OMIM: 604504; MGI: 2146901; HomoloGene: 99728; GeneCards: TRIP10; OMA:TRIP10 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 6,737,925 bp [1] End 6,751,530 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 D Start 57,556,455 bp [2] End 57,570,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle gastric mucosa apex of heart ectocervix Descending thoracic aorta muscle layer of sigmoid colon right coronary artery ascending aorta right ovary Top expressed in interventricular septum muscle of thigh skeletal muscle tissue triceps brachii muscle lip temporal muscle ankle sternocleidomastoid muscle extraocular muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding lipid binding GTPase activator activity Cellular component cytoplasm cytosol Golgi apparatus cell projection intracellular membrane-bounded organelle membrane plasma membrane nucleoplasm cell cortex perinuclear region of cytoplasm lysosome phagocytic cup cytoskeleton extracellular exosome Biological process endocytosis cell communication regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity actin cytoskeleton organization membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9322 106628 Ensembl ENSG00000125733 ENSMUSG00000019487 UniProt Q15642 Q8CJ53 RefSeq (mRNA) NM_001288962 NM_001288963 NM_004240 NM_001242389 NM_001242390 NM_001242391 NM_134125 RefSeq (protein) NP_001275891 NP_001275892 NP_004231 NP_001229318 NP_001229319 NP_001229320 NP_598886 Location (UCSC) Chr 19: 6.74 – 6.75 Mb Chr 17: 57.56 – 57.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene. ^{[5] [6] [7] [8]}

Interactions

TRIP10 has been shown to interact with STAT3, ^[9] Wiskott-Aldrich syndrome protein, ^[10] Huntingtin, ^[11] CDC42, ^{[6] [10]} AKAP9 ^[12] and RHOQ. ^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000125733 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019487 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi: 10.1210/mend.9.2.7776974 . PMID   7776974.
6. Aspenstrom P (August 1997). "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton". Curr Biol. 7 (7): 479–87. doi: 10.1016/S0960-9822(06)00219-3 . PMID   9210375. S2CID   14268690.
7. Tsuji E, Tsuji Y (April 2001). "Molecular cloning and chromosomal localization of human salt-tolerant protein". Genetica. 108 (3): 259–62. doi:10.1023/A:1004132919896. PMID   11294612. S2CID   22725257.
8. "Entrez Gene: TRIP10 thyroid hormone receptor interactor 10".
9. Chung, Young-Hwa; Cho Nam-hyuk; Garcia Maria Ines; Lee Sun-Hwa; Feng Pinghui; Jung Jae U (June 2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12). United States: 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. ISSN   0022-538X. PMC   416526 . PMID   15163742.
10. Tian, L; Nelson D L; Stewart D M (March 2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11). UNITED STATES: 7854–61. doi: 10.1074/jbc.275.11.7854 . ISSN   0021-9258. PMID   10713100.
11. Holbert, Sébastien; Dedeoglu Alpaslan; Humbert Sandrine; Saudou Frédéric; Ferrante Robert J; Néri Christian (March 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5). United States: 2712–7. Bibcode:2003PNAS..100.2712H. doi: 10.1073/pnas.0437967100 . ISSN   0027-8424. PMC   151406 . PMID   12604778.
12. Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (June 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6). United States: 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN   1059-1524. PMC   420101 . PMID   15047863.
13. Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20). United States: 12835–40. Bibcode:2002PNAS...9912835C. doi: 10.1073/pnas.202495599 . ISSN   0027-8424. PMC   130546 . PMID   12242347.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Tian L, Nelson DL, Stewart DM (2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. 275 (11): 7854–61. doi: 10.1074/jbc.275.11.7854 . PMID   10713100.
• Linder S, Hüfner K, Wintergerst U, Aepfelbacher M (2001). "Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages". J. Cell Sci. 113 Pt 23 (23): 4165–76. doi:10.1242/jcs.113.23.4165. PMID   11069762.
• Richnau N, Aspenström P (2001). "Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1". J. Biol. Chem. 276 (37): 35060–70. doi: 10.1074/jbc.M103540200 . PMID   11431473.
• Yuan R, Fan S, Achary M, et al. (2001). "Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage". Cancer Res. 61 (21): 8022–31. PMID   11691828.
• Wang L, Rudert WA, Grishin A, et al. (2002). "Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms". Biochem. Biophys. Res. Commun. 293 (5): 1426–30. doi:10.1016/S0006-291X(02)00398-4. PMID   12054674.
• Chang L, Adams RD, Saltiel AR (2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12835–40. Bibcode:2002PNAS...9912835C. doi: 10.1073/pnas.202495599 . PMC   130546 . PMID   12242347.
• Dombrosky-Ferlan P, Grishin A, Botelho RJ, et al. (2003). "Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup". Blood. 101 (7): 2804–9. doi: 10.1182/blood-2002-03-0851 . PMID   12456510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Holbert S, Dedeoglu A, Humbert S, et al. (2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2712–7. Bibcode:2003PNAS..100.2712H. doi: 10.1073/pnas.0437967100 . PMC   151406 . PMID   12604778.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID   12736724.
• Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Mol. Vis. 9: 449–59. PMID   14502124.
• Larocca MC, Shanks RA, Tian L, et al. (2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. PMC   420101 . PMID   15047863.
• Chung YH, Cho NH, Garcia MI, et al. (2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. PMC   416526 . PMID   15163742.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yin X, Warner DR, Roberts EA, et al. (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID   15752756.